Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer by Fan-Fan Shang (16953264)

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First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

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Protein levels of Bcl-2 family markers in limbal stromal cells (LSCs) and in Aniridia-LSCs (AN-LSCs), after treatment with 0 µM, 50 µM and 75 µM Cobalt chloride (CoCl₂),... by Shanhe Liu (5251313)

FTY720 treatment decreased tumor growth in a xenograft model of hepatoblastoma. by Laura L. Stafman (6577184)

“…When tumors reached an average of 150 mm³, mice were randomized to receive vehicle (ORA-Plus, 50 μL, n = 7) or FTY720 (10 mg/kg body weight/day in ORA-Plus, 50 μL, n = 7) by oral gavage for 16 days. …”

Increased lipid accumulation and decreased klotho expressions in palmitate-treated mouse podocytes. by Jeong Suk Kang (7359572)

“…Boxes are enlarged images of representative lipid droplets. magnification 20x; scale bar = 50 μm and 100 μm. (c) Western blot showing the decreased expression of klotho and nephrin proteins by palmitate treatment. …”

Terpenoids decrease single-channel activity of L-AChRs elicited by ACh. by Guillermina Hernando (553795)

Conditional <i>Aff4</i> knockout decreases fat mass in mice. by Yaqian Chen (1711576)

Cyclooxygenase inhibition decreases immune control of fungal germination and invasive hyphal growth. by Savini Thrikawala (5690510)

Histogram of number of drugs with (a) increased and (b) decreased usage within 12 months. by Nguyen Thach (20347852)

Apicoplast inhibitors decrease global parasite prenylation in the second IDC after treatment. by Kit Kennedy (4915510)

S12 Data - by Christoph Anders (4068499)

“…The study was conducted with 25%, 50%, and 75% of the upper body weight. Additionally, we varied the starting point (forward tilt and backward tilt) and the direction of rotation. …”

mTORC1 hyperactivation led to a decreased autophagic activity in the podocytes. by Wakiko Iwata (8600457)

“…The white box indicates the location of the magnified figure. Scale bar: 50 μm. (<b>bottom, right</b>) Quantitative analysis of autophagic activity <i>in vivo</i>. …”

The introduction of mutualisms into assembled communities increases their connectance and complexity while decreasing their richness. by Gui Araujo (22170819)

“…<p>Using the invasion model, we investigate the effect of switching on and off (black vs grey) invasions with mutualisms halfway through the simulation (i.e. after 500 assembly events). …”

Numbers of all fractures, arranged in order of decreasing mean age and with proportion of each of the fracture types in patients over 50, 65, and 75 years of age. by Camilla Bergh (9904522)

“…<p>Numbers of all fractures, arranged in order of decreasing mean age and with proportion of each of the fracture types in patients over 50, 65, and 75 years of age.…”

HE staining results of lung tissue of guinea pigs in each group (×200,scale = 50μm). by Fangwei Xu (11845586)

Absence of Jag2 alleviates hypoxia-induced oxidative stress injury in rats. by Hanhan Liu (568151)

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Jag2 expression is upregulated in hypoxia-treated rats and PASMCs. by Hanhan Liu (568151)

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Inhibition of Jag2 effectively ameliorates hypoxia-induced PH in rats. by Hanhan Liu (568151)

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Summary results of the logistic regression model M2-12 including the significant two-way interactions to maximise loglikelihood. by Dennis Ochola (11626912)

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FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. by Laura L. Stafman (6577184)

“…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD₅₀ = 8.4 μM, p ≤ 0.05). (B) Following 24 hours of treatment with FTY720, the proliferation of HuH6 cells measured using the CellTiter 96 cell proliferation assay was significantly decreased (IC₅₀ = 6.4 μM, p ≤ 0.05). …”