يعرض 121 - 140 نتائج من 11,883 نتيجة بحث عن '(((( 50 μ decrease ) OR ( e point decrease ))) OR ( 50 ((ns decrease) OR (we decrease)) ))', وقت الاستعلام: 0.46s تنقيح النتائج
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    Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer حسب Xingchen Liu (524190)

    منشور في 2021
    "…As a vital kinase in the glycolysis system, PKM2 is extensively expressed in colorectal cancer (CRC) to support the energy and biosynthetic needs. In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC<sub>50</sub> = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC<sub>50</sub> = 0.66 μM) and SW480 (IC<sub>50</sub> = 0.22 μM) cells. …"
  11. 131

    Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer حسب Xingchen Liu (524190)

    منشور في 2021
    "…As a vital kinase in the glycolysis system, PKM2 is extensively expressed in colorectal cancer (CRC) to support the energy and biosynthetic needs. In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC<sub>50</sub> = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC<sub>50</sub> = 0.66 μM) and SW480 (IC<sub>50</sub> = 0.22 μM) cells. …"
  12. 132

    Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer حسب Xingchen Liu (524190)

    منشور في 2021
    "…As a vital kinase in the glycolysis system, PKM2 is extensively expressed in colorectal cancer (CRC) to support the energy and biosynthetic needs. In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC<sub>50</sub> = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC<sub>50</sub> = 0.66 μM) and SW480 (IC<sub>50</sub> = 0.22 μM) cells. …"
  13. 133

    Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer حسب Xingchen Liu (524190)

    منشور في 2021
    "…As a vital kinase in the glycolysis system, PKM2 is extensively expressed in colorectal cancer (CRC) to support the energy and biosynthetic needs. In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC<sub>50</sub> = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC<sub>50</sub> = 0.66 μM) and SW480 (IC<sub>50</sub> = 0.22 μM) cells. …"
  14. 134

    Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer حسب Xingchen Liu (524190)

    منشور في 2021
    "…As a vital kinase in the glycolysis system, PKM2 is extensively expressed in colorectal cancer (CRC) to support the energy and biosynthetic needs. In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC<sub>50</sub> = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC<sub>50</sub> = 0.66 μM) and SW480 (IC<sub>50</sub> = 0.22 μM) cells. …"
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