Kylo-0603’s EC50 & tissue levels. by Xueqin lu (22250795)

Impact of DNA extraction process on depth of coverage. by Lizhi Yu (12476136)

MBIC50 and MBEC50 values (µg/mL) of synthesized 1,2,3,5-tetrazine derivatives against bacteria pathogen strains. by Jean Paul Dzoyem (6424445)

Subjects:

Drive dynamics for split^<50cM <i>ClvR</i>s with different genetic linkage and migration rates. by Georg Oberhofer (3401438)

Oral administration of TVSE decreases angiogenesis in 4T1 tumors in BALB/c mice. by Hyun Sook Lee (8039876)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

miR-200c decreases KLOTHO expression in HK-2 cells by translational repression. by Kenichi Morii (6843554)

Cell line characterization and combination effect of KRAS G12C inhibitors and pemigatinib. by Angela Abdollahi (15166230)

PCR-RFLP detection results of the three new SNPs (g.-1293C>G, g.56T>C, g.7017C>T) in bovine <i>C3</i> gene. by Yonghui Wang (287491)

Subjects:

Host population bottlenecks decrease microbiome diversity. by Michael Ørsted (5926028)

Effect of seed priming on anti-oxidants and lipid peroxidation in pearl millet at 50 DAS. by N. K. Gupta (11211399)

Decreasing fluconazole susceptibility of clinical South African <i>Cryptococcus neoformans</i> isolates over a decade by Serisha D. Naicker (8648370)

Shows the protein fragment of C3: The signal peptide and the alpha and beta chains, which consist of the C3a and C3b fragment. by Yonghui Wang (287491)

Subjects:

Simulations that now also include an <i>asymmetric</i> indoors/outdoors model, with a threshold temperature of 17.5C in spring, and 25C in fall. by Sebastian A. Müller (10688740)

5-hmC is increased during THP1 macrophage differentiation. by Fangfang Sun (2410654)

Comparison of mean differences in temperature decreases. by Hans-Jörg Gillmann (8460585)

Fluid loss and hydration in CON (n = 22) and HOT (n = 17) surgeries; Decrease in body mass in kg (A), decrease in body mass in % of total body mass (B), rate of decrease in body ma... by Zehra Palejwala (7507409)

Relationship between the decrease in hunting licences and excess mortality, in each province: Relationship in 2020–2021 (a), in 2021–2022 (b) and between 2021–2022 licences and 202... by Jacopo Cerri (6271958)

Baseline level biochemical and circulating biomarkers in study subjects. by Jaskiran Kaur (160829)