Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. حسب Xiaowen Jiang (8291814)

Identification, Synthesis, and Biological Evaluations of Potent Inhibitors Targeting Type I Protein Arginine Methyltransferases حسب Xiao Li (107004)

"…In this study, we first identified several hit compounds against CARM1 by structure-based virtual screening (IC₅₀ = 35.51 ± 6.68 to 68.70 ± 8.12 μM) and then carried out chemical structural optimizations, leading to six compounds with significantly improved activities targeting CARM1 (IC₅₀ = 18 ± 2 to 107 ± 6 nM). …"

Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis حسب Chenlu Zhang (508309)

"…Evidence showed that intestinal FXR antagonism exhibited remarkable metabolic improvements in mice. Herein, we developed a series of betulinic acid derivatives as potent intestinal FXR antagonists, and <b>F6</b> was identified as the most potent one with an IC₅₀ at 2.1 μM. …"

Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis حسب Chenlu Zhang (508309)

"…Evidence showed that intestinal FXR antagonism exhibited remarkable metabolic improvements in mice. Herein, we developed a series of betulinic acid derivatives as potent intestinal FXR antagonists, and <b>F6</b> was identified as the most potent one with an IC₅₀ at 2.1 μM. …"

Germ cell size decreases before corpse formation. حسب Tea Kohlbrenner (19476160)

The decrease or inhibition of Hsp90 induced REST degradation. حسب Raúl Orozco-Díaz (7067624)

"…(D) The level of REST dramatically reduced in differentiated SH-SY5Y cells treated with GA (1 μM) or PU-H71 (50 nM) at 24 h. (E) The REST level decreased by GA more than 50% and (F) PU-H71 more than 80%, respectively. …"

HFD induces LDs and decreases ER and mitochondria in nephrocytes. حسب Aleksandra Lubojemska (10746241)

"…Note that LDAH::GFP induces clustering of LDs [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001230#pbio.3001230.ref038" target="_blank">38</a>]. …"

Kinase profiler assay of 1C8 (10 μM). حسب Florentin Pastor (19852287)

TTLL12 knockdown in HEp-2 and DU145 cells decreases cell survival in the presence of nitrotyrosine. حسب Amit Deshpande (255211)

The aging-induced decrease in the number of dendritic branches in neurons of the hippocampus and cerebral cortex was attenuated by the administration of GTDE. حسب Hui-Chuan Kuo (12368492)

Data_Sheet_1_Perceptual Priming Can Increase or Decrease With Aging.PDF حسب Kalathupiriyan A. Zhivago (9659504)

"…To measure implicit perceptual memory, we used a classic perceptual priming paradigm. Participants had to report the shape of a visual search pop-out target whose color or position was varied randomly across trials. …"

Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses حسب Jing Wang (6206297)

"…However, how global land use changes impact soil N supply and potential N loss remains elusive. By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …"

LOH resulting in 189R/R produces a strong decrease in drug susceptibility. حسب Pétra Vande Zande (17628246)

DataSheet_1_Canavanine-Induced Decrease in Nitric Oxide Synthesis Alters Activity of Antioxidant System but Does Not Impact S-Nitrosoglutathione Catabolism in Tomato Roots.pdf حسب Pawel Staszek (7407689)

"…Genes coding glutathione peroxidase were upregulated by 50-µM CAN, while 10-µM CAN downregulated GSHPx1. …"

The synchronous activity of SGN fiber populations is disrupted and their response to sound is decreased with increasing levels of <i>L</i>_<i>u</i> heterogeneity. حسب Maral Budak (6680351)

SIINFEKL-specific CD8⁺ T cells treated with anti-CXCR3 decreased the polyfunctionality. حسب Camila Pontes Ferreira (6194006)

Illustrates photographs of the CAM were captured to visualize the vascular plexus following the control group, native-orientin (5 μM), native-orientin (10 μM), NF-O (5 μM), and NF-... حسب Yashwanth Elumalai (21743452)

Cytotoxicity (as of %Control) IC₅₀ value (mean ±SD in µM) of the tested compounds vs. Positive controls Cisplatin and doxorubicin against gastrointestinal and colorectal... حسب MohammedBashar Al-Qazzan (22439236)

Flow chart of the study procedures. حسب Kazuhiko Ikeuchi (9234268)

"…Pre-treatment spontaneous decrease of RPR titer was associated with a slower decrease in post-treatment RPR titer.…"

The treatment with anti-CXCR3 decreases the number of CD8⁺ T cells in the heart. حسب Camila Pontes Ferreira (6194006)