VPS34 inhibition decreases intracellular levels of cholesteryl-esters, blocks cholesterol uptake and enhances lysosomal degradation of LDLR. by Marek J. Kobylarz (9292599)

Trial profile. by Chanel Avenant (409756)

“…Both contraceptives substantially decreased, from D0 to 25W, the total testosterone [DMPA-IM D0 0.560, 25W 0.423 nmol/L, -24.3% (p < 0.0001); NET-EN D0 0.551, 25W 0.253 nmol/L, -54.1%, (p < 0.0001)], SHBG [DMPA-IM D0 45.0, 25W 32.7 nmol/L, -29.8% (p < 0.0001); NET-EN D0 50.2, 25W 17.6 nmol/L, -65.1% (p < 0.0001)], and calculated free testosterone levels [DMPA-IM D0 6.87, 25W 5.38 pmol/L, -17.2% (p = 0.0371); NET-EN D0 6.00, 25W 3.70, -40.0% (p < 0.0001)]. …”

Correlation between urinary Br- levels and ERP indices in all participants before (n = 50) and after (n = 50) work. by Jungmi Choi (4740150)

The inhibitory activity of the most active compounds against Glo-I enzyme with less than 50 µM. Their supportive corresponding docking values on two different protocols are display... by MohammedBashar Al-Qazzan (22439236)

Oral administration of TVSE decreases angiogenesis in 4T1 tumors in BALB/c mice. by Hyun Sook Lee (8039876)

Decreased ISCs and increased goblet cells after intestinal specific loss of MLL1. by Neha Goveas (11790822)

“…<p><b>(A)</b> Kaplan-Meier survival curve. Tamoxifen was given by gavage for 6 days to mice with the genotype <i>Mll1</i>^{<i>FC/+; Vil-Cre-ERT2/+</i>} (n = 12) and <i>Mll1</i>^{<i>FC/FC; RC/+</i>} (n = 18). …”

EGFR/ERK signaling activity decreases throughout LEC elimination with endocytic activity dependency. by Kevin Yuswan (19845885)

Cinacalcet administered early in the inactive phase markedly decrease parathyroid Ki-67 index. by Søren Egstrand (10906087)

“…Each dot represents one sample. Scale bars measures 50μm.</p>…”

Running increased neural stem cell proliferation in the dentate gyrus, but did not decrease inflammation. by Kaja Falkenhain (9317016)

Exposure to low CO₂ levels decreases ER cholesterol levels. by Nityanand Bolshette (17396845)

“…<b>(F)</b> qPCR analysis for cholesterogenic genes from NIH3T3 cells exposed to cholesterol (50 μm) or 25-hydroxycholesterol (10 μm) under 5% or 1% CO₂ for 4 h (mean ± SE, <i>n</i> = 3 biological replicates per condition, ***<i>P</i> < 0.001, nonsignificant (ns), two-way ANOVA with Bonferroni’s multiple comparisons test). …”

Cancellous bone microarchitecture assessed by μCT of the distal femur from 8.5–9 week old <i>Notch3</i>^{<i>em1Ecan</i>} mutant (gray bars) male mice and sex-matched litter... by Ernesto Canalis (516050)

Cortical bone microarchitecture assessed by μCT of the mid-diaphyseal femur from 8.5–9week old <i>Notch3</i>^{<i>em1Ecan</i>} mutant (gray bars) male mice and sex-matched l... by Ernesto Canalis (516050)

<i>In vitro</i> activity of aryl-thiazole derivatives against <i>Schistosoma mansoni</i> schistosomula and adult worms by Adriana S. A. Pereira (5900249)

“…After <i>in vitro</i> treatment for five days with 6.25 μM NJ05 or NJ07 separately, we observed a decrease of 30% in schistosomula viability, whilst treatment with NJ05+NJ07 lead to a reduction of 75% in viability measured by ATP quantitation and propidium iodide labeling. …”

Fitting curve of rock E₅₀. by Junxia Zhou (14381598)

THRα/β EC₅₀ values and selectivity of test compounds. by Xuan G. Luong (9761423)

One-way sensitivity analysis, <i>Immediate ART</i> strategy compared to <i>ART<350/μL</i>. by Eric N. Ouattara (6890174)

Effect of seed priming on anti-oxidants and lipid peroxidation in pearl millet at 50 DAS. by N. K. Gupta (11211399)

Trace-weighted images at b = 50 s/mm². by Tobit Führes (12647099)

Discovery of Novel Substituted <i>N</i>‑(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors by Jimin Xu (2208961)

“…Notably, among these derivatives, compound <b>15</b> showed improved anti-HAdV activity (IC₅₀ = 0.27 μM), significantly decreased cytotoxicity (CC₅₀ = 156.8 μM), and low <i>in vivo</i> toxicity (maximum tolerated dose = 150 mg/kg in hamster) as compared with niclosamide, supporting its further <i>in vivo</i> efficacy studies for the treatment of HAdV infections.…”

MCF-7 cells were treated with 0, 10, or 20 μM of Peptide 1 or Peptide 2 for 48h. by Deepu Dowarha (5673440)