Showing 121 - 140 results of 18,313 for search '(((( 50 a decrease ) OR ( 50 μ decrease ))) OR ((( 50 nn decrease ) OR ( 10 re decrease ))))', query time: 0.40s Refine Results
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    Synthesis, Biological Evaluation, Structure–Activity Relationship, and Mechanism of Action Studies of Quinoline–Metronidazole Derivatives Against Experimental Visceral Leishmaniasi... by Akanksha Upadhyay (6732857)

    Published 2019
    “…Among all synthesized derivatives, <b>15b</b> and <b>15i</b> showed significant antileishmanial efficacy against both extracellular promastigote (IC<sub>50</sub> 9.54 and 5.42 μM, respectively) and intracellular amastigote (IC<sub>50</sub> 9.81 and 3.75 μM, respectively) forms of Leishmania donovani with negligible cytotoxicity toward the host (J774 macrophages, Vero cells). …”
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    Medium-Ring Keto Bislactams with Antischistosomal Activity by Rongguo Ren (2943366)

    Published 2024
    “…Aryl substitution with EWG functional groups decreased the chemical stability. These compounds were relatively polar with the measured LogD<sub>7.4</sub> values ranging from <0 to 2.4, had kinetic aqueous solubilities between 40 and >320 μM, and had relatively low cytotoxicities with IC<sub>50s</sub> ranging from 52 to >390 μM. …”
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    Fig 3 - by Lihong Gu (513505)

    Published 2024
    Subjects:
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