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Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv...
Published 2023“…However, GSIS data showed no difference in c-peptide secretion between low (2.8mM) and high (20 mM) glucose but high response to direct cellular depolarization-mediated c-peptide by KCl; suggesting a lack of functional β-cells. Interestingly, addition of Exendin-4 (50 nM) during the last 3 days of the differentiation significantly enhanced GSIS associated with increased expression of glucose-sensing apparatus genes (Glut2, G6P2C, GCK) and genes encoding mitochondrial oxidative phosphorylation machinery.…”
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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
Published 2025“…We envisage that the NB2E3 nanobody-2× Mpro biosensor engineered here will be useful in drug discovery and functional characterization of Mpro mutants in newly emerging SARS-CoV-2 variants as well as in detecting SARS-CoV-2 infection in a point-of-care testing (POCT) format.…”
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Experimental investigations on the performance of a thermo-mechanical refrigeration system utilizing ultra-low temperature waste heat sources
Published 2023“…Thus, this study fills a significant gap in the literature by (i) experimentally evaluating the performance of a new full-scale thermo-mechanical refrigeration (TMR) system at ultra-low temperatures ranging from 50 °C to 85 °C, (ii) characterizing its operation with different commercial refrigerants, and (iii) identifying optimal operating conditions and working fluids for the investigated TMR system. …”
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Diagnosing type 2 diabetes using Hemoglobin A1c: a systematic review and meta-analysis of the diagnostic cutpoint based on microvascular complications
Published 2020“…</p><h3>Conclusions</h3><p dir="ltr">The prevalence of nephropathy and moderate retinopathy was increased in subjects with HbA1c values ≥ 6.5% confirming the high specificity of this value for diagnosing T2DM; however, at HbA1c < 6.5% retinopathy increased at age > 55 years and, most strikingly, in African-Americans, suggesting there may be excess microvascular complication prevalence (particularly nephropathy) in individuals below the diabetes diagnostic threshold.…”
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Carotid artery revascularization through a radiated field
Published 2003“…Radiation-induced accelerated atherosclerosis has been recognized for some time.1, 2, 3 and 4 Because of the prolonged survival of patients treated with radiation,5 the frequency of this long-term side effect is expected to increase. In a prospective study, late (>70%) carotid artery stenosis was found in 11.7% of 240 patients who had undergone cervical irradiation.6 The chronic effects of radiation therapy lead to decreased vascularity and increased fibrosis, which in turn lead to risk for tissue necrosis, infection, and ulceration. …”
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Performance of Different Concrete Types Exposed to Elevated Temperatures: A Review
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Turning solid waste incineration ashes into a usable material in construction
Published 2003“…The variation of strength ranged between an increase of 12% and a decrease of 50% depending on the proportions, gradation, and source of ashes added. …”
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Antibody‐based methods for the measurement of α‐synuclein concentration in human cerebrospinal fluid – method comparison and round robin study
Published 2018“…<p dir="ltr">α‐Synuclein is the major component of Lewy bodies and a candidate biomarker for neurodegenerative diseases in which Lewy bodies are common, including Parkinson's disease and dementia with Lewy bodies. …”
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Thermoelectric power of (Cu0.5Tl0.5)-1223 superconducting phase added with BaSnO3 nanoparticles
Published 2017“…Superconducting transition temperature (Tc) increases up to 117.5 for x = 0.25 wt.% and then it decreases with further x addition. …”
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Chromogranin A‐positive hormone‐negative endocrine cells in pancreas in human pregnancy
Published 2023“…However, an increase in the percentage of clustered β-cells was found in pregnancy, with decreased frequency of other endocrine cells in clusters, suggesting a compensatory shift from other pancreatic endocrine cell types to β-cells as a mechanism to meet the increased insulin demands of pregnancy.…”
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Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study
Published 2024“…Hepatic glucose output increased from 0.6 (0.5–0.7) to 1.5 (1.3–1.7) mmol/min, while arterial lactate increased from 0.8 (0.7–0.9) to 9.0 (8.1–9.9) mmol/L (<i>P</i> < 0.05) despite a rise in hepatic lactate uptake. …”
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Characterization of Dse1 a candida albicans cells wall protein. (c2009)
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Experimental investigations on the performance of a thermo-mechanical refrigeration system utilizing ultra-low temperature waste heat sources
Published 2023“…Thus, this study fills a significant gap in the literature by (i) experimentally evaluating the performance of a new full-scale thermo-mechanical refrigeration (TMR) system at ultra-low temperatures ranging from 50 °C to 85 °C, (ii) characterizing its operation with different commercial refrigerants, and (iii) identifying optimal operating conditions and working fluids for the investigated TMR system. …”
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Dynamics of Neisseria gonorrhoeae transmission among female sex workers and clients: A mathematical modeling study
Published 2024“…Interventions substantially reduce incidence. Increasing condom use from 10 % to 50 % lowers NG prevalence among FSWs, clients, and their spouses from 12.2 % to 6.4 %, 1.2 % to 0.5 %, and 0.4 % to 0.2 %, respectively. …”
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Green Inhibition of Mild Steel Corrosion in a CO2 Saturated Saline Solution
Published 2015Get full text
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