Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant by Ittipat Meewan (7455041)

“…Several drugs targeting the protease have been developed, but drug-resistant mutant strains emerged. Here, we screened a library and synthesized a novel class of small molecules based on a tryptophan derivative scaffold identified as HCV NS3/4A protease inhibitors that are active against both wild type and mutant form of the protease. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. by Xiaowen Jiang (8291814)

Atomically Precise Au₄₂ Nanorods with Longitudinal Excitons for an Intense Photothermal Effect by Yingwei Li (701628)

“…Compared to other rod-shaped nanoclusters, Au₄₂ possesses a much more effective photothermal conversion with a large temperature increase of ∼27 °C within 5 min (λ_ex = 808 nm, 1 W cm^–2) at an ultralow concentration of 50 μg mL^–1 in toluene. …”

DAF-16/FOXO is Required for Locomotory Healthspan and Lifespan Benefits of Genetic Glycolysis Disruption. by Brian Onken (86790)

“…<i>daf-16</i> mutants are documented to have lowered locomotory ability vs. WT later in life [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.ref091" target="_blank">91</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.ref092" target="_blank">92</a>]; we note that, although comparison of scores across experiments is not possible due to variation in baseline values, the swimming rate of <i>daf-16(mgDf50)</i> control animals was slightly lower than WT controls on the same day of life (in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.g001" target="_blank">Fig 1C</a>; mean of 46.17 head thrashes/30 sec. for <i>daf-16</i> vs. 52.17 head thrashes/30 sec. for WT on day 10). …”

Disrupting Glycolysis-promoting Genes Extends <i>C</i>. <i>elegans</i> Healthspan, Whereas High Glucose and Gluconeogenic Gene Disruptions Shorten Healthspan. by Brian Onken (86790)

“…<i>elegans</i> ORF designations indicated). We note that, in our hands, disruption of C50F4.2 (<i>pfk-1</i>.…”

S2 Fig - by Xinyue Yang (629144)

“…Sprague-Dawley (SD) rats were randomly divided into four groups: normal saline (NS), and 50 (50-cur), 100 (100-cur), and 200 mg/kg curcumin (200-cur) groups. …”

S1 Fig - by Xinyue Yang (629144)

“…Sprague-Dawley (SD) rats were randomly divided into four groups: normal saline (NS), and 50 (50-cur), 100 (100-cur), and 200 mg/kg curcumin (200-cur) groups. …”

S1 Data - by Xinyue Yang (629144)

“…Sprague-Dawley (SD) rats were randomly divided into four groups: normal saline (NS), and 50 (50-cur), 100 (100-cur), and 200 mg/kg curcumin (200-cur) groups. …”