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ms decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
nn decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
nm decrease » _ decrease (Expand Search), a decrease (Expand Search), gy decreased (Expand Search)
50 ms » 50 mg (Expand Search), 50 mm (Expand Search)
5 nm » 5 mm (Expand Search), 5 cm (Expand Search)
ms decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
nn decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
nm decrease » _ decrease (Expand Search), a decrease (Expand Search), gy decreased (Expand Search)
50 ms » 50 mg (Expand Search), 50 mm (Expand Search)
5 nm » 5 mm (Expand Search), 5 cm (Expand Search)
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Synthesis and Biological Evaluation of Peripheral 5HT<sub>2B</sub> Antagonists for Liver Fibrosis
Published 2025“…<b>19c</b> showed robust <i>in vitro</i> activity with an IC<sub>50</sub> value of 1.09 nM and limited blood–brain barrier penetration. …”
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Synthesis and Biological Evaluation of Peripheral 5HT<sub>2B</sub> Antagonists for Liver Fibrosis
Published 2025“…<b>19c</b> showed robust <i>in vitro</i> activity with an IC<sub>50</sub> value of 1.09 nM and limited blood–brain barrier penetration. …”
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Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents
Published 2021“…One of the synthesized derivatives, compound <b>23h</b> (R<sup>1</sup> = MeSO<sub>2</sub>, R<sup>2</sup> = 1-piperidin-4-amine, R<sup>3</sup> = 3-Cl-4-F-aniline) displayed potent inhibitory effects in the in vitro assays (52% inhibition in the protein-based assay at 100 nM and an IC<sub>50</sub> value of 181 nM in the serum HBV DNA quantification assay). …”
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Table_1_Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts.DOCX
Published 2020“…However, EMPA did specifically decrease cardiac lactate labeling in the <sup>13</sup>C glucose perfusions (<sup>13</sup>C labeling of lactate: 58 ± 2% vs. 50 ± 3%, for vehicle and EMPA, respectively; P = 0.02), without changes in other glucose metabolic pathways. …”
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The injectable contraceptives depot medroxyprogesterone acetate and norethisterone enanthate substantially and differentially decrease testosterone and sex hormone binding globulin...
Published 2025“…Both contraceptives substantially decreased, from D0 to 25W, the total testosterone [DMPA-IM D0 0.560, 25W 0.423 nmol/L, -24.3% (p < 0.0001); NET-EN D0 0.551, 25W 0.253 nmol/L, -54.1%, (p < 0.0001)], SHBG [DMPA-IM D0 45.0, 25W 32.7 nmol/L, -29.8% (p < 0.0001); NET-EN D0 50.2, 25W 17.6 nmol/L, -65.1% (p < 0.0001)], and calculated free testosterone levels [DMPA-IM D0 6.87, 25W 5.38 pmol/L, -17.2% (p = 0.0371); NET-EN D0 6.00, 25W 3.70, -40.0% (p < 0.0001)]. …”