Results isoprenaline (30nM) experiment. by L. Cao (3526226)

Concentrations of particles that caused significant decreases in the viability of SNU-1 cells compared to untreated cells during 1, 2, 4, 6 or 24 h treatment periods. by Amrita Banerjee (382658)

Effects of TGF-β1 on the expression of fibrosis indicators in HBdSMCs and the effects of MEL on the expression of fibrosis indicators in HBdSMCs induced by TGF-β1. by Yang Zhang (30734)

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects by Xiaopeng Peng (9136955)

“…The most potent compound <b>NT-6</b> exhibited high tubulin polymerization inhibitory activity (IC₅₀ = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC₅₀ of 30 nM, better than colchicine and the hit compound <b>1f</b> (IC₅₀ of 65 and 126 nM, respectively). …”

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects by Xiaopeng Peng (9136955)

“…The most potent compound <b>NT-6</b> exhibited high tubulin polymerization inhibitory activity (IC₅₀ = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC₅₀ of 30 nM, better than colchicine and the hit compound <b>1f</b> (IC₅₀ of 65 and 126 nM, respectively). …”

Fig 5 - by Zhi Zhang (55283)

Increased levels of PPARγ and decreased levels of adiponectin in thymus from rats administered cocaine for 7 days. by Kana Unuma (283272)

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Metformin lotion decreases collagen III levels in the wounded skin of rats after 10 days of wound healing. by Jianying Zhang (256508)

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Metformin lotion decreases collagen III levels in the wounded skin of rats after 10 days of wound healing. by Jianying Zhang (256508)

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Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. by Xiaowen Jiang (8291814)

ROC curve and P-R curve (attack traffic proportion = 50%). by Longyan Ran (18452261)

Metformin lotion decreases TGF-β1 levels in the wounded skin of rats after 10 days of wound healing. by Jianying Zhang (256508)

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Overexpressions of the AB domain of RPA70 and the β-barrel domain of Ku70 significantly decrease HBoV1 replication in HAE-ALI. by Kang Ning (59789)

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Number of samples per site during the study period. by Winnie Okore (14139712)

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Performance of selected antimalarials against field isolates during the study period. by Winnie Okore (14139712)

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<i>Pfmrp1</i> gene SNPs data during the study period. by Winnie Okore (14139712)

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Performance of selected drugs against field isolates during the study period. by Winnie Okore (14139712)

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Frequency of SNPs in <i>Pfmrp1</i> gene in field isolates during the study period. by Winnie Okore (14139712)

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