First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

"…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …"

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

"…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …"

FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. حسب Laura L. Stafman (6577184)

"…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD₅₀ = 8.4 μM, p ≤ 0.05). …"

E₅₀ values. حسب Junxia Zhou (14381598)

Predicting pattern diversity decreases as a function of and . حسب Selim Haj Ali (21222613)

"…(a) and (b): Average negative predictive value for and , respectively for and . …"

Minimum quorum sensing inhibitory concentrations (MQSICs), minimum inhibitory concentrations (MICs), and concentrations inhibiting 50% of violacein production (IC50s) of compounds... حسب Jean Paul Dzoyem (6424445)

الموضوعات:

Decreased glycosylated α-DG and laminin levels distal to the glial dome in <i>Large</i>^{<i>myd/myd</i>} mice. حسب Shigefumi Morioka (8893511)

Secondary structure profile analysis for the SP domain of native PC and its mutant structures over 200 ns MD simulation times. حسب Mahvash Farajzadeh-Dehkordi (17468232)

<i>Bbs1</i>^{<i>M390R/M390R</i>} mice have decreased hippocampal proliferation. حسب Thomas K. Pak (10686881)

"…The Red Bar line represents 50μm. G.) Decreased proliferation in the dentate gyrus of P3 <i>Bbs1</i>^{<i>M390R/M390R</i>} mice. …"

NS affects the PI3K/AKT/mTOR pathway in RAW264.7 cells. حسب Yihua Wang (491766)

Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. حسب Xiaowen Jiang (8291814)

The fraction of predicted heterozygotes that are set to “No Call” by RHA decreases as the size of the heterozygote cluster increases. حسب Orna Mizrahi-Man (42539)

EQI decreases malonyl-CoA levels in <i>S</i>. <i>aureus</i>. حسب Erica C. Larson (1344687)

Test characteristics for identifying stenosis ≥ 50% in any limb from aorta till popliteal artery in the overall population (<i>n = 126 limbs</i>). حسب O. Stivalet (6890189)

VANGL2 recruits MARCH8 to promote the K27-linked ubiquitination of NLRP3. حسب Huaji Jiang (16907514)

VANGL2 recruits NLRP3 to OPTN for selective autophagic degradation. حسب Huaji Jiang (16907514)

Free energy landscape (FEL) analysis for the SP domain of native PC and its mutant structures over 200 ns MD simulation times. حسب Mahvash Farajzadeh-Dehkordi (17468232)

Dose response of airways to Methacholine shows a decreased contractility in <i>GSTCD</i>^-/- mouse lungs following LPS treatment. حسب Bo Liu (127343)

E₅₀ values of angle. حسب Junxia Zhou (14381598)

Curve fitting of E₅₀. حسب Junxia Zhou (14381598)