Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

<i>eIF2A</i> overexpression decreases the cell wall protein levels. by Laura Meyer (4033793)

The catalase enzyme response of <i>A</i>. <i>albopictus</i> larvae decreased (1.5-fold) in response to <i>M</i>. <i>robertsii</i>-derived copper nanoparticles. by Perumal Vivekanandhan (4863484)

Selected features for balanced random forest for each model in decreasing importance. by Yves Carpentier Solorio (10684335)

Pairwise comparisons of hormonal results for DMPA-IM vs NET-EN expressed as mean percentage differences (95% CI) (mITT analysis). by Chanel Avenant (409756)

Dominant positive effect of mutated versions of <i>PTR1</i>. by Sophia Bigot (16469992)

Inactivation of one allele of FT5. by Sophia Bigot (16469992)

<i>S</i>. Typhimurium coordinates protein synthesis with protein folding capacity. by Carissa Chan (18310140)

K-means clustering was performed to cluster the genes according to their expression kinetics. by Seon-Pil Jin (17364626)

A reduction in protein synthesis furthers bacterial survival against Mg²⁺ starvation. by Carissa Chan (18310140)

Percentage decreases in scores of self-reported health, large muscle function, and mobility by chronic diseases per wave after disease incidence. by James Davis (2267599)

E₅₀ values. by Junxia Zhou (14381598)

Plot of mean secondary trauma stress by group and time. by Kunal Desai (18784208)

Endoscopic injection into the vocal fold muscle. by Ikuo Mikoshiba (9312007)

HPx1 expression is controlled by dietary heme and the E75 transcription factor. by Octavio A. C. Talyuli (4285141)

Tax expression is associated with decreased cellular motility. by Saumya Ramanayake (7879091)

Data_Sheet_1_Microclimatic Warming Leads to a Decrease in Species and Growth Form Diversity: Insights From a Tropical Alpine Grassland.PDF by Sisimac A. Duchicela (11503918)

“…Furthermore, cushions and herbs decreased inside OTCs. Our results show that experimental warming using OTCs in equatorial regions leads to decreased daily thermal amplitude and night temperatures rather than the level of increase in mean temperatures observed in temperate regions. …”