Overexpressions of the AB domain of RPA70 and the β-barrel domain of Ku70 significantly decrease HBoV1 replication in HAE-ALI. by Kang Ning (59789)

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

NgR1 KO mice exhibited an increase in excitatory synapses and a decrease in inhibitory synapses, indicating an imbalance of synaptic transmission. by Jinwei Zhang (462455)

“…The inhibitory synaptic density of NgR1 mice showed a significant decrease when compared to WT mice (***P <  0.001). …”

Molecular Simulations Probing the Adsorption and Diffusion of Ammonia, Nitrogen, Hydrogen, and Their Mixtures in Bulk MFI Zeolite and MFI Nanosheets at High Temperature and Pressur... by Roshan Patel (10727011)

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Changes in cyanobacteria fluorescence with 75 μg/mL H₂O₂ for 5, 8, 17 and 24 days. by Emma T. Brentjens (17295999)

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Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. …”

Diabetic wounds show increased amounts of vessel leakage and decreased pericyte coverage. by Uzoagu A. Okonkwo (8754933)

Decrease in vRNA in brain during antiretroviral therapy. by Sonny R. Elizaldi (9684796)

oAβ enhances lysosomal acidification in NG and HG mixed glia cultures. by Yung-Cheng Huang (3443450)

High resolution structures visible with the 25 nm zone plate objective. by Kamal L. Nahas (13014698)

“…(<b>F</b>) The width of nuclear capsids was remeasured after imaging with the 25 nm zone plate: 124.5 nm ± 0.96 nm SEM (n = 80 from 4 tomograms; 8.55 nm SD). …”

S1 Data - by Francois Kiemde (5369657)

“…Venous blood was collected at scheduled visit: Visit 1 (V1; 16–20 weeks of amenorrhea), Visit 2 (V2; 28 ±1 weeks of pregnancy), Visit 3 (V3; 32 ±1 weeks of pregnancy), Visit4 (V4; delivery) and Visit5 (V5; 6–7 weeks after delivery). …”

Characteristic of study population. by Francois Kiemde (5369657)

“…Venous blood was collected at scheduled visit: Visit 1 (V1; 16–20 weeks of amenorrhea), Visit 2 (V2; 28 ±1 weeks of pregnancy), Visit 3 (V3; 32 ±1 weeks of pregnancy), Visit4 (V4; delivery) and Visit5 (V5; 6–7 weeks after delivery). …”

Atomically Precise Au₄₂ Nanorods with Longitudinal Excitons for an Intense Photothermal Effect by Yingwei Li (701628)

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Digital Microfluidic Platform Based on Printed Circuit Board for Affinity Evaluation of Mertansine Aptamers by Dongliu Xiang (10688647)

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Confocal images of oAβ internalization by astrocytes in NG and HG mixed glia cultures. by Yung-Cheng Huang (3443450)