Antibacterial potential of ethyl acetate extract against <i>S</i>. <i>aureus</i> and MRSA (STR = streptomycin; CHL = chloramphenicol). by Shivankar Agrawal (11565095)

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Effects of ethyl acetate extract on the ultrastructure of <i>S</i>. <i>aureus</i> and MRSA as observed by SEM (A, control; B, <i>S</i>. <i>aureus</i>; C, MRSA). by Shivankar Agrawal (11565095)

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Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis by Chenlu Zhang (508309)

Subjects:

Identification, Synthesis, and Biological Evaluations of Potent Inhibitors Targeting Type I Protein Arginine Methyltransferases by Xiao Li (107004)

Subjects:

Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis by Chenlu Zhang (508309)

Subjects:

Optical Control of Insect Behavior and Receptors with Azobenzene-Bridged Fipronil and Imidacloprid by Wen Fu (2040040)

“…IMI-AB-FIP in both <i>trans</i>/<i>cis</i> isomers can be reversibly interconverted depending on light, accompanied by insecticidal activity decrease or increase by 1.5–2.3 folds. In addition, IMI-AB-FIP displayed synergistic effects against A. craccivora (LC_{50, IMI‑AB‑FIP} = 14.84–22.10 μM, LC_{50, IMI‑AB‑IMI} = 210.52–266.63 μM, LC_{50, and FIP‑AB‑FIP} = 36.25–51.04 μM), mainly resulting from a conceivable reason for simultaneous targeting on both GABARs and nAChRs. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Penidaleodiolides A and B, Cage-Like Polyketides with Neurotransmission-Regulating Activity from the Soil Fungus <i>Penicillium daleae</i> L3SO by Qing-Yuan Wang (11571890)

“…Penidaleodiolide A (<b>1</b>) showed a significant inhibitory effect on the action potentials of murine hippocampal basket neurons and decreased the frequency of spontaneous excitatory postsynaptic currents in a concentration-dependent manner (the inhibition ratios were 0.30 ± 0.02 for 1 μM, 0.37 ± 0.03 for 10 μM, and 0.50 ± 0.07 for 20 μM) while being devoid of cytotoxicity against the nerve cells.…”

ROS and superoxide decrease in the dormant form of mycobacteria. by Amar Yeware (7115063)

Tax expression is associated with decreased cellular motility. by Saumya Ramanayake (7879091)

Cigarette smoke decreases clathrin mediated endocytosis. by Parker F. Duffney (8878145)

HFD decreases nephrocyte uptake of dextran and albumin. by Aleksandra Lubojemska (10746241)

Diabetic kidney shows decreased klotho expression. by Jeong Suk Kang (7359572)

“…Boxes are enlarged images of representative klotho expression in podocytes and tubules. magnification 40x; scale bar = 50 μm. (b) Verification of klotho expression in immortalized mouse and human podocytes compared to human tubule cells by Western blot. …”

The decrease in blood flow disrupts CV pruning. by Lin Wen (557398)

Follicle stem cell proliferation was severely reduced when Wg was tethered to the plasma membrane. by Xiaoxi Wang (130742)

Viral inhibition assay in combination of VPA with or without fixed dose (25 μM)of both DHA and LA. by Amanda Watson (4447267)