The expression of miR-214 (A) and the activating transcription factor 4 (<i>ATF4</i>) target gene (B) after treating K562 cells with 25, 50, and 75 μM of hemin for 48 h. حسب Tipparat Penglong (164413)

Dropwise Condensation in Ambient on a Depleted Lubricant-Infused Surface حسب Durgesh Ranjan (15333712)

"…Condensation heat transfer further deteriorates in the presence of non-condensable gases (NCGs) requiring special experimental arrangements to eliminate NCGs due to a decrease in the availability of nucleation sites. To address these issues while simultaneously improving heat-transfer performance of LIS in condensation-based systems, we report fabrication of both fresh LIS and a lubricant-depleted LIS using silicon porous nanochannel wicks as an underlying substrate. …"

Drugs susceptibility profile (EC₅₀ values and Fold-change) to the antileishmanials in all polyene resistant lines of <i>Leishmania</i> spp. حسب Edubiel A. Alpizar-Sosa (13848145)

"…<p>Mean EC₅₀ values (μM) ± Standard Deviation (SD). …"

Fitting curve of rock E₅₀. حسب Junxia Zhou (14381598)

Targeting hTERT Promoter G‑Quadruplex DNA Structures with Small-Molecule Ligand to Downregulate hTERT Expression for Triple-Negative Breast Cancer Therapy حسب Wei Long (411482)

"…Ligand <b>5</b> showed high affinity toward hTERT G4 (<i>K</i>_d = 1.1 μM) and potent activity against triple-negative breast cancer cells (MDA-MB-231, IC₅₀ = 1 μM). …"

Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks حسب Sofia Benfeito (4345591)

"…As opposed to <b>Mito.TPP</b>, these novel compounds were not cytotoxic to SH-SY5Y and HepG2 cells up to 50 μM and after 24 h of incubation. All of the cationic derivatives accumulated inside the mitochondrial matrix and acted as neuroprotective agents against iron(III), hydrogen peroxide, and <i>tert</i>-butyl hydroperoxide insults. …"

Synthesis, Biological Evaluation, Structure–Activity Relationship, and Mechanism of Action Studies of Quinoline–Metronidazole Derivatives Against Experimental Visceral Leishmaniasi... حسب Akanksha Upadhyay (6732857)

"…Among all synthesized derivatives, <b>15b</b> and <b>15i</b> showed significant antileishmanial efficacy against both extracellular promastigote (IC₅₀ 9.54 and 5.42 μM, respectively) and intracellular amastigote (IC₅₀ 9.81 and 3.75 μM, respectively) forms of Leishmania donovani with negligible cytotoxicity toward the host (J774 macrophages, Vero cells). …"

Sequence of <i>DpAP2</i> promoter. حسب Lingru Ruan (18995544)

"…<i>parva</i> cells treated with different concentrations of MeJA (10, 20, 50, 100 μM) and GA3 (10, 20, 50, 100 μM). The high concentrations of MeJA (10–100 μM) inhibited the accumulation of carotenoid, and the relative expression of <i>DpAP2</i>, <i>PSY</i>, <i>PDS</i> and <i>GGPS</i> decreased significantly. …"

Predicted <i>cis</i>-acting elements in <i>DpAP2</i> promoter. حسب Lingru Ruan (18995544)

"…<i>parva</i> cells treated with different concentrations of MeJA (10, 20, 50, 100 μM) and GA3 (10, 20, 50, 100 μM). The high concentrations of MeJA (10–100 μM) inhibited the accumulation of carotenoid, and the relative expression of <i>DpAP2</i>, <i>PSY</i>, <i>PDS</i> and <i>GGPS</i> decreased significantly. …"

One-way sensitivity analysis, <i>Immediate ART</i> strategy compared to <i>ART<350/μL</i>. حسب Eric N. Ouattara (6890174)

Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients - Fig 3 حسب Tomoyoshi Komiyama (474366)

"…B: Isoproterenol was decreased by 5 mM for each 1/10 at the following concentrations: 5 nM, 50 nM, 500 nM, 5 μM, 50 μM, 500 μM, and 5 mM. …"

Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells حسب Yang Li (7082)

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Fourteen days after tMCAo surgery mice with RNS60 treatment show a decrease in microglial activation Iba1 (+) in the CA3 region of the ipsilateral hippocampus. حسب Gloria Patricia Baena-Caldas (17721328)

Zwitterion-Functionalized Cuprous Oxide Nanoparticles for Highly Specific and Enzymeless Electrochemical Creatinine Biosensing in Human Serum حسب R. K. Rakesh Kumar (14241205)

"…A linear response to creatinine concentration from 10 to 200 μM (<i>R</i>² = 0.9876 and LOD = 5.0 μM) was observed, which covers the entire range of physiological creatinine in human serum. …"

Developmental toxicity induced by 2 μg/ml propofol. حسب Yali Ge (417371)

In <i>Drosophila</i> DSK and TO inhibits Gr64f gene transcription and optogenetic activation of Dsk-GAL4 neurons decreases the sensitivity of gustatory neurons in starved flies. حسب Di Guo (718480)

"…(<b>F</b>) Expression pattern of <i>Dsk</i>-GAL4 in the brain revealed by anti-GFP (F1) and anti-DSK (F2). Scale bars, 50 μm. (<b>G</b>) Electrophysiological recordings reveal that starved flies (24 h) show increased sensitivity of GRNs compared with refed flies (fed 1.5 h after starvation) and optogenetic activation of <i>Dsk</i>-GAL4 neurons (30 min) decreases the sensitivity of gustatory neurons in starved flies (24 h). …"

Table_1_Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts.DOCX حسب Hong Zhang (25820)

"…However, EMPA did specifically decrease cardiac lactate labeling in the ¹³C glucose perfusions (¹³C labeling of lactate: 58 ± 2% vs. 50 ± 3%, for vehicle and EMPA, respectively; P = 0.02), without changes in other glucose metabolic pathways. …"

Effect of Safr and Cands on the levels of complex I (U/mg protein), complex II (U/mg protein), complex IV (U/mg protein), caspase-3 (Casp-3, μg/mg protein), Fas ligand (FasL, μg/mg... حسب Nagwa Ibrahim Shehata (17319689)

Discovery and Pharmacological Studies of 4‑Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis حسب José Ignacio Manzano (7908449)

"…We report the discovery of new 4-hydroxyphenyl phosphonium salt derivatives active in the submicromolar range (EC₅₀ from 0.04 to 0.28 μM, SI > 10) against the protozoan parasite Leishmania donovani. …"

ABT199 inhibits ALK ^mutant kinase activity and decreases it phosphorylation. حسب Richard Junior Zapata Dongo (17912565)