يعرض 121 - 140 نتائج من 4,766 نتيجة بحث عن '(((( 50 nn decrease ) OR ( 50 na decrease ))) OR ( 50 n decrease ))', وقت الاستعلام: 1.14s تنقيح النتائج
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    Discovery of 2‑Ethoxy-5-isobutyramido‑<i>N</i>‑1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects حسب Jie Zhou (28945)

    منشور في 2023
    "…In this work, a series of novel benzamide derivatives were designed and synthesized as Kv2.1 inhibitors, and extensive structure–activity relationships led to highly potent and selective Kv2.1 inhibitors having IC<sub>50</sub> values of 10<sup>–8</sup> M. Among them, compound <b>80</b> (IC<sub>50</sub> = 0.07 μM, selectivity >130 fold over other K<sup>+</sup>, Na<sup>+</sup>, and Ca<sup>2+</sup> ion channels) was able to decrease the apoptosis of HEK293/Kv2.1 cells induced by H<sub>2</sub>O<sub>2</sub>. …"
  6. 126

    Discovery of 2‑Ethoxy-5-isobutyramido‑<i>N</i>‑1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects حسب Jie Zhou (28945)

    منشور في 2023
    "…In this work, a series of novel benzamide derivatives were designed and synthesized as Kv2.1 inhibitors, and extensive structure–activity relationships led to highly potent and selective Kv2.1 inhibitors having IC<sub>50</sub> values of 10<sup>–8</sup> M. Among them, compound <b>80</b> (IC<sub>50</sub> = 0.07 μM, selectivity >130 fold over other K<sup>+</sup>, Na<sup>+</sup>, and Ca<sup>2+</sup> ion channels) was able to decrease the apoptosis of HEK293/Kv2.1 cells induced by H<sub>2</sub>O<sub>2</sub>. …"
  7. 127

    Discovery of 2‑Ethoxy-5-isobutyramido‑<i>N</i>‑1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects حسب Jie Zhou (28945)

    منشور في 2023
    "…In this work, a series of novel benzamide derivatives were designed and synthesized as Kv2.1 inhibitors, and extensive structure–activity relationships led to highly potent and selective Kv2.1 inhibitors having IC<sub>50</sub> values of 10<sup>–8</sup> M. Among them, compound <b>80</b> (IC<sub>50</sub> = 0.07 μM, selectivity >130 fold over other K<sup>+</sup>, Na<sup>+</sup>, and Ca<sup>2+</sup> ion channels) was able to decrease the apoptosis of HEK293/Kv2.1 cells induced by H<sub>2</sub>O<sub>2</sub>. …"
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    Expanding Three-Coordinate Gold(I) Anticancer Agent Chemical Space حسب Charles E. Greif (21728091)

    منشور في 2025
    "…The complexes demonstrated submicromolar cytotoxic activity against human breast cancer cells MDA-MB-231 or MDA-MB-468 with IC<sub>50</sub>’s in the range of 0.4–5.0 μM. Complex <b>2e</b> shows high potency in vitro and decreases 3D-breast cancer mammosphere viability. …"
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