PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications by Pramod Darvin (153341)

“…The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …”

Modulation of SLFN11 induces changes in DNA Damage response in breast cancer by Christophe Michel Raynaud (17449906)

“…As oncogenic transcriptomic downregulation is often driven by methylation of the promotor region, we explore the demethylation effect of 5-aza-2′-deoxycytidine (decitabine), on the SLFN11 gene. …”

Wales’ tourists not a burden for local healthcare by Nature Research (16552612)

“…<p>Researchers in southern Wales reviewed nine-years-worth of hospital data and found non-Welsh residents accounted for only 0.5% of unintentional injuries presenting to an emergency department.…”

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Alize J, Ferrari

“…Non-communicable diseases contributed 1·73 billion (95% UI 1·54–1·94) DALYs in 2021, with a decrease in age-standardised DALY rates since 2010 of 6·4% (95% UI 3·5–9·5). …”
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Low-Dose Eltrombopag in a Patient with Chronic Idiopathic Thrombocytopenic Purpura Post Sleeve Gastrectomy by Mohanad A. Ahmed (14777299)

“…Here we are reporting a 46-year-old female with ITP and sleeve gastrectomy who responded to low-dose eltrombopag 25 mg every other day, which is equivalent to 12.5 mg daily, and maintained adequate platelet counts on this dose.…”

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma by Peter Kubatka (11008854)

“…In addition, treated tumors showed significant dose-dependent decrease in mitotic activity index by 36.5% and 51% in comparison with the control group. …”

Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy by Samson Mathews Samuel (18808246)

“…Assays for cell proliferation, migration and tubulogenesis were also performed. We observed robust up-regulation of anti-angiogenic thrombospondin-1 (TSP1) and increased TSP1-CD36 co-localization with a marked decrease in the levels of phosphorylated vascular endothelial growth factor receptor-2 (pVEGFR2; Y1175) in 2DG (5 mM) exposed cells treated with metformin (2 mM). …”

Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India? by Habib Hasan Farooqui (7861166)

“…We conducted interrupted time series analyses by fitting a Poisson regression model. …”

Simultaneous Bilateral Neck of Femur Fracture in a Young Adult with Underlying Metabolic Disturbances by Eslam Alkaramani (14570439)

“…<em>Conclusion</em>. We report this rare case of bilateral neck of femur fracture in a young adult after a generalized seizure attack with underlying metabolic disturbances. …”

Characterizing the dynamics of climate and native desert plants in Qatar by Meshal Abdullah (17746950)

“…By analyzing Landsat satellite images from 1985 to 2022 and their relation to rainfall patterns, we found significant impacts of climatic variables on vegetation coverage, particularly after 1990. …”

BRET-Based Biosensors for Nucleic Acid Detection and Impact of Molecular Crowding Monitoring by Asfia Sultana (19170880)

“…</p><p dir="ltr">We observed the structural fluctuation of flexible linker compared to rigid linker. …”

The protective role of lidocaine in surgeries involving trigeminal nerve manipulation: a meta-analysis of trigeminocardiac reflex prevention by Almonzer Al-Qiami (22393303)

“…This leads to a rapid increase in parasympathetic activity, resulting in a decrease in heart rate (HR) and blood pressure, which can potentially lead to bradycardia, and cardiac arrest, with a prevalence of 14.5% during neurointerventional procedures (8). …”

Generalized and pregnancy-related anxiety prevalence and predictors among pregnant women attending primary health care in Qatar, 2018–2019 by Sarah Naja (9954737)

“…Furthermore, we conducted a Confirmatory Factor Analysis for the utilized scales.…”

Endocrine contribution to the sexual dysfunction in patients with advanced chronic kidney disease and the role of hyperprolactinemia by Haitham Elbardisi (14058048)

“…<p dir="ltr">In this study, we investigated the prevalence of sexual dysfunction among males with advanced chronic kidney disease and the effect of treating hyperprolactinemia among these patients. …”

Walking around the preferred speed: examination of metabolic, perceptual, spatiotemporal and stability parameters by Lina Majed (7485380)

“…While metabolic, perceptual and spatiotemporal values were sensitive to the smallest change in speed (i.e., 0.5 km·h⁻¹⁾, a significant increase in the rate of carbohydrate oxidation and decrease in % fat oxidation were only observed at speeds above PWS. …”

Dispatchable capacity optimization strategy for battery swapping and charging station aggregators to participate in grid operations by Mingze Zhang (9947863)

“…Also, the aggregator does not worsen the original power load while meeting the EV swapping demand and can decrease the daily load fluctuations by 0.65% and 12.89%, reduce the peak–valley difference by 5.81% and 7.80%, and increase the load rate by 3.67% and 4.08% in working and non-working day situations through providing the dynamic dispatchable capacity for the grid.…”

Dispatchable capacity optimization strategy for battery swapping and charging station aggregators to participate in grid operations by Mingze, Zhang

“…Also, the aggregator does not worsen the original power load while meeting the EV swapping demand and can decrease the daily load fluctuations by 0.65% and 12.89%, reduce the peak–valley difference by 5.81% and 7.80%, and increase the load rate by 3.67% and 4.08% in working and non-working day situations through providing the dynamic dispatchable capacity for the grid.…”
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Analyzing the Influence of Climate and Anthropogenic Development on Vegetation Cover in the Coastal Ecosystems of GCC by Abhilash Dutta Roy (22466830)

“…Our results revealed significant changes in land cover, as seen by an increase in artificial built-up areas by 15.5% in two decades and a corresponding decrease in bareland and dense vegetation. …”

Retinal imaging based glaucoma detection using modified pelican optimization based extreme learning machine by Debendra Muduli (20748758)

“…The effectiveness has been evaluated using two standard datasets called G1020 and ORIGA with the $$10 \times 5$$-fold stratified cross-validation technique to ensure reliable evaluation. …”

Qatar’s immigrants at higher risk of diabetes by Nature Research (16552612)

“…The researchers stress, however, that their preliminary results should be confirmed in future studies involving larger numbers of participants. 1 “We would advise the Qatari government to screen all immigrants entering the country, as this would decrease the risk of unnecessary complications due to the late diagnosis of diabetes,” says lead author Dennis Mook-Nakamori. …”