GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age. by Nicole K. Polinski (10947787)

“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”

TUDCA decreases ER stress in HOX neonatal rat lungs. by Kirkwood A. Pritchard Jr. (13449794)

“…(<b>C</b>) In IHC stain, P-IRE1α levels are decreased (40.8±3.5 A.U. <i>vs</i> 53.1±5.0 A.U., p<0.001, n = 6, 3 for each sex) in chronic hyperoxia exposed neonatal rat lungs by TUDCA. …”

S1 Dataset - by Nelmo Jordão Manjate (16324619)

Subjects:

Analysis of human aneurysmal and normal aortic tissues. by Dong Ma (584680)

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The effect of Mdivi-1 administration on cell apoptosis in vivo. by Dong Ma (584680)

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Representative TUNEL- and DAPI-stained sections from the abdominal aortas of young and old WT and smcKlf5^−/− mice following 28 days of Ang II infusion. by Dong Ma (584680)

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Young (3 months) or old (18 months) WT and smcKlf5^−/− mice were infused with Ang II for 28 days. by Dong Ma (584680)

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Adaptation to cool temperature decreases basal and stimulated lipolysis and increases <i>de novo</i> lipogenesis and TAG synthesis. by Hiroyuki Mori (512656)

“…(<b>H</b>) Quantification of autoradiography for labeled TAG was by ImageJ. <i>n =</i> 5, data are mean ± SD. *<i>p</i> < 0.05. Uncropped western blots are provided in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000988#pbio.3000988.s016" target="_blank">S1 Raw Images</a>, and numerical data for all graphs are provided in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000988#pbio.3000988.s014" target="_blank">S6 Data</a>. …”

PPM1A facilitates both nuclear distribution and transcription potency of YAP/TAZ. by Ruyuan Zhou (10197187)

“…<b>(B–D)</b> Transcription potency of YAP (5 ng), which was suppressed by coexpression of MST1 (50 ng) (B), LATS1 (500 ng) (C), or MAP4K1 (50 ng) (D), was markedly recovered by cotransfection of wild-type PPM1A but not the enzyme-dead PPM1A (D239N). …”

Taste bud cell populations are decreased after <i>Sox2</i> deletion in epithelial stem/progenitor cells. by Makoto Ohmoto (3065106)

Conditional ablation of <i>Ybx1</i> leads to a reduction in cortical progenitor cell pool and a decrease in cortical thickness. by Jian Zhang (1682)

HoxA9-ER directly represses <i>Cebpa</i> gene expression in myeloid cells. by Lei Peng (260321)

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Simulated effects of increased pCREB combined with decreased pCaMKIIα on bistability. by Yili Zhang (540283)

“…<p>(A1) Modification of model. Increased basal phosphorylation of CREB <i>k</i>_{<i>basalp_creb</i>}, concurrent with decreased basal phosphorylation of CaMKIIα <i>k</i>_{<i>basalp_CaMKII</i>}, in the absence of the effects of MeCP2/HDAC2/Sin3a (red) ([<i>E</i>_<i>comp</i>] = 0; [<i>E</i>_<i>MeCP2</i>] = 0). …”

Mean (±1SD) better of the two eyes’ monocular FMTs and binocular flicker thresholds across 13 subjects plotted for mesopic condition as a function of target size. by C. Vijay Reena Durai (14498259)

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Mean (±1SD) better of the two eyes’ monocular FMTs and binocular flicker thresholds across 13 subjects plotted for photopic condition as a function of target size. by C. Vijay Reena Durai (14498259)

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A picture of the 50 L small-scale environmental chamber. by Eloise Parry-Nweye (7548998)

50 WT 5′ and 3′ terminal nts of the S1 gene are sufficient to package a non-MRV gene into infectious virions. by Debarpan Dhar (724473)

Growth on stiff substrate results in mild lifespan extension but a decrease in organismal health. by Maria Oorloff (19658113)

GXM decreases the trans-endothelial electrical resistance (TEER) and transmigration of <i>C</i>. <i>neoformans</i> through HBECs in a blood brain barrier (BBB) model. by Hiu Ham Lee (15374677)

LOH resulting in 189R/R produces a strong decrease in drug susceptibility. by Pétra Vande Zande (17628246)