Maximum concentrations (ng/L) of 88 pharmaceuticals detected at least once (in order of decreasing number of detections across all regions and samples) in water samples from wadeab... by Paul M. Bradley (523469)

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Changes of anti-oxidative enzyme and oxidative stress after in a mouse model of kidney fibrosis. by Wencheng Jin (13136262)

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NatB-inactivation decreased Drk levels through its N-terminal sequences, which was regulated by the N-end rule E3 ubiquitin ligase POE/UBR4. by Zhentao Sheng (107495)

“…Data were collected from eye discs containing MARCM clones similar to those shown in (A-C). (E-J) Wing discs containing FRT control or <i>psid</i> MARCM clones marked by GFP expression (pointed by arrowheads). …”

Repeated LSPC treatment prolongs survival of and decreases PrP^Res accumulation in a subset of prion-infected mice. by Heather Bender (363996)

Data_Sheet_1_Microclimatic Warming Leads to a Decrease in Species and Growth Form Diversity: Insights From a Tropical Alpine Grassland.PDF by Sisimac A. Duchicela (11503918)

“…We installed five monitoring blocks in 2012 at ca. 4,200 m asl with 20 OTCs and 50 control plots randomly distributed within each block. …”

Bacterial intracellular survival increases <i>in vivo</i> persistence in a mouse model of urinary tract infection and decreases antibiotic efficacy. by Cristina Penaranda (433703)

Reference mutations versus background noise across replicates. by Lizhi Yu (12476136)

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Quantification and accuracy of average VAF. by Lizhi Yu (12476136)

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Analytical sensitivity and reproducibility. by Lizhi Yu (12476136)

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Depth of coverage and heterogeneity of the mutation loci. x-axis, mutation loci in sample set one or two; y-axis, depth of coverage after UMI consolidation. by Lizhi Yu (12476136)

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Impact of mutation type on VAF quantification performance. by Lizhi Yu (12476136)

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Schematic overview of the cross-platform study. by Lizhi Yu (12476136)

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Impact of DNA extraction process on depth of coverage. by Lizhi Yu (12476136)

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Supplementary data 1: database with extracted data from Combined effects of warming and drought on plant biomass depend on plant woodiness and community type: a meta-analysis by Rutger A. Wilschut (13853921)

Average nearest neighbour analysis before and after filtering of data points. by Dennis Ochola (11626912)

Comparison of network throughput between eHMP and EOPAPS. by Khong-Lim Yap (8357256)

Evaluation of glucose consumption and lactate production in culture medium of HL-1 cells exposed to LG, NG, HG and IHG during 12 and 72h. by Patrick Mordel (17020879)

Brain uptake rate of [¹⁴C]docosahexaenoic acid (DHA) in the whole brain and each brain region. by Takuro Iwao (14636741)

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