Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…Decreased formation and increased clearance of MG-derived AGEs may be associated with healthy aging in the HSA-mUCP1 mouse.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…Decreased formation and increased clearance of MG-derived AGEs may be associated with healthy aging in the HSA-mUCP1 mouse.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes. حسب Ramanjaneya, Manjunath

"…Apoproteins apoA2, apoC1, apoC3 and apoE are decreased in women with GDM and may have a role in inflammation, as apoA2 and C3 correlated with CRP. …"
احصل على النص الكامل
احصل على النص الكامل

Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein inter... حسب Thirumal Kumar, D.

"…From the analysis, we observed the highest deviation with lowest compactness and a decrease in the intramolecular h-bonds in the BRCA1-BARD1 protein complex with the V11G mutation compared to the native complex or the complexes with other mutations. 2022 Elsevier Inc.…"
احصل على النص الكامل
احصل على النص الكامل

Investigation of solar PV performance under Doha weather using a customized measurement and monitoring system حسب Touati, Farid

"…A key factor in future eco-friendly and reliable energy systems for network stability is energy prediction of renewable resources. …"
احصل على النص الكامل
احصل على النص الكامل

Study of Magnetic Properties and Lattice Dynamics of the Cdx Co1-x Ferrite System by MossbauerEffect حسب Eissa, N. A. [نبيل عيسى]

"…The Neel temperature was found to decrease with increasing cadmium concentration. The reduced hyperfine magnetic fields for the A- and the B- sites were found to follow the Brillouin function and One-Third-Power Law. …"
احصل على النص الكامل

Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects حسب Alsaad A.M.

"…This was associated with a marked decrease (50%) in the expression of detoxifying genes (NQO1 and GSTA1) with an increase in CYP1A1 mRNA expression, a cancer-activating gene. …"
احصل على النص الكامل
احصل على النص الكامل

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach حسب P., Sneha

"…Second, the sequence conservation and DNA-binding sites of the mutant positions were assessed; as HNF1A protein is a transcription factor. Finally, the biochemical properties of the biological system were validated using molecular dynamic simulations in Gromacs 4.6.3 package. …"
احصل على النص الكامل
احصل على النص الكامل

Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2. حسب P, Sneha

"…Galactosemia type 2 is an autosomal recessive disorder characterized by the deficiency of galactokinase (GALK) enzyme due to missense mutations in GALK1 gene, which is associated with various manifestations such as hyper galactosemia and formation of cataracts. …"
احصل على النص الكامل
احصل على النص الكامل

Mossbauer Effect Study of the Cations Distribution and its Influence on the Electric Field Gradient of the Cdx Co1-x Ferrite System حسب Eissa, N. A. [نبيل عيسى]

"…In the ferrite system Cd,Co,_x Fe; 04 (X=0.0, O.I, 0.2, ....... , 1.0). it was found that the introduction of Co2'1' decrease the EFG at the octahedral B-site. …"
احصل على النص الكامل

Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies حسب Fawaz E., Alanazi

"…This study aims to investigate the inhibitory effect of metformin on VISTA via AHR in melanoma cells (CHL-1, B16) and animal models. VISTA and AHR levels were assessed by qPCR, Western blot, immunofluorescence microscope, flow cytometry, and immunohistochemistry. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies حسب Fawaz E., Alanazi

"…This study aims to investigate the inhibitory effect of metformin on VISTA via AHR in melanoma cells (CHL-1, B16) and animal models. VISTA and AHR levels were assessed by qPCR, Western blot, immunofluorescence microscope, flow cytometry, and immunohistochemistry. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Ubiquitin-Related Modifier 1 (URM-1) Modulates Cx43 in Breast Cancer Cell Lines. حسب El-Hajjar, Layal

"…The significant upregulation of small ubiquitin-like modifier-1 (SUMO-1) was also observed. In cells with downregulated URM-1, Cx43 expression significantly decreased, and SUMOylation by SUMO-1 was affected. …"
احصل على النص الكامل
احصل على النص الكامل

Heme Oxygenase Isoform 1 Regresses Cardiomyocyte Hypertrophy Through Regressing Sodium Proton Exchanger Isoform 1 Activity حسب Sobh, Ahmed

"…Results: Our results showed a significant decrease in HO-1 mRNA expression in cardiomyocytes expressing active NHE1 (74.84 ± 9.19 % vs. 100 % normal NHE1 expression, p<0.05). …"
احصل على النص الكامل
احصل على النص الكامل

Experimental and numerical investigation of the flexural behavior of one-way RC slabs strengthened with near-surface mounted and externally bonded systems حسب Aljidda, Omar

"…In contrast, the slabs reinforced with EB experienced a decrease in ductility ranging from 38 % to 50 %. …"
احصل على النص الكامل
احصل على النص الكامل

Towards An Effective Urban Growth Management Strategy In Qatar (1) حسب Al Thani, F. A. Rahman

"…This paper aim at reviews the current problems associated with the lack of an urban growth management strategy in the State of Qatar and outlines the process of creating a comprehensive system to effectively handle urban growth. …"
احصل على النص الكامل

Molecular properties prediction, anticancer and anti-inflammatory activities of some pyrimido[1,2-b]pyridazin-2-one derivatives حسب Zeiz, Ali

"…Introduction: The anticancer and anti-inflammatory activities of a novel series of eleven pyrimido[1,2-b]pyridazin-2-one analogues substituted at position 7 were assessed in the current study. …"
احصل على النص الكامل
احصل على النص الكامل

The Cardiovascular Benefits of Empagliflozin, A Sodium Glucose Cotransporter Inhibitor: Is NHE1 a Viable Target? حسب Al-Shamasi, Al-Anood

"…Empagliflozin (EMPA), an SGLT2 inhibitor (with a low affinity for SGLT1) has attracted much attention due to a recent clinical trial, the Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG OUTCOME). …"
احصل على النص الكامل
احصل على النص الكامل

Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor. حسب Padmanabhan, Regina

"…Nevertheless, further studies are imperative to substantiate this argument and to uncover the potential crosstalk between PD-1/PD-L1 inhibitors and HER2 growth signaling pathways in breast cancer.…"
احصل على النص الكامل
احصل على النص الكامل

Mycoplasma bovis-induced inhibition of bovine peripheral blood mononuclear cell proliferation is ameliorated after blocking the immune-inhibitory programmed death 1 receptor حسب Suleman M.

"…We demonstrated that M. bovis infection induced a significant decrease in CD4+ PD-1INT and CD8+ PD-1INT subsets with intermediate PD-1 expression, which functioned as progenitor pools giving rise to CD4+ PD-1HIGH and CD8+ PD-1HIGH subsets with high PD-1 expression levels. …"
احصل على النص الكامل
احصل على النص الكامل