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HRMECs treated with SUZ12 siRNA demonstrate increased miR-200b expression, decreased VEGF expression and decreased endothelial branching.
Published 2015“…<p><b>A,B:</b> Gene knockdown of EZH2 and SUZ12 was confirmed by qPCR. <b>C,D:</b> In HRMECs transfected with EZH2 siRNA in HG, miR-200b and VEGF were not significantly different from HG+control siRNA but decreased compared to NG+control siRNA. …”
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HRMECs treated with 3-Deazaneplanocin A (DZNep) chemical inhibitor demonstrated increased miR-200b and decreased VEGF expression.
Published 2015“…<b>B,C:</b> In parallel levels of VEGF mRNA and secreted VEGF protein were decreased in HRMECs treated in HG with DZNep compared to controls. …”
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The rate of lariat formation is decreased two-fold by isoginkgetin treatment.
Published 2014“…The height of each bar indicates the fold change, from vehicle- to isoginkgetin-treated cells, in the mean fraction of reads aligning to each genic feature (<i>p</i><0.02 from two-tailed <i>t</i>-tests for all ratios). …”
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