Search alternatives:
a decrease » _ decreased (Expand Search), _ decreases (Expand Search)
_ decrease » _ decreased (Expand Search), _ decreases (Expand Search), _ decreasing (Expand Search)
w decrease » _ decreased (Expand Search), _ decreases (Expand Search)
_ akt » _ art (Expand Search)
2 w » 2 wt (Expand Search)
a decrease » _ decreased (Expand Search), _ decreases (Expand Search)
_ decrease » _ decreased (Expand Search), _ decreases (Expand Search), _ decreasing (Expand Search)
w decrease » _ decreased (Expand Search), _ decreases (Expand Search)
_ akt » _ art (Expand Search)
2 w » 2 wt (Expand Search)
-
1
Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells
Published 2017“…Failure of PE to induce PC3 damage in cells overexpressing Akt further confirms its implication in the PE-elicited cell death. …”
Get full text
Get full text
Get full text
-
2
-
3
Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines
Published 2018“…Treatment with GC suppressed constitutively phosphorylated AKT and downregulated expression of inhibitor of apoptotic proteins XIAP, cIAP-1, and cIAP-2. …”
Get full text
Get full text
-
4
-
5
-
6
Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach.
Published 2019“…From the simulation studies, we observed higher deviation, lower protein compactness, and a decrease in the number of intramolecular hydrogen bonds in the mutant W764C MSH2-MSH6 protein complex. …”
Get full text
Get full text
-
7
-
8
Salvia fruticosa Induces Vasorelaxation in Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway
Published 2017“…Furthermore, SF induced Akt phosphorylation as well as increased cGMP levels in rings treated with increasing doses of SF. …”
Get full text
Get full text
-
9
-
10
Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Published 2019“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
Get full text
Get full text
-
11
Signaling pathways activated by PACAP in MCF-7 breast cancer cells
Published 2018“…Moreover, selective inhibition of Src or PI3K resulted in a significant decrease in the phosphorylation of ERK and AKT, but not p38, demonstrating that PACAP signaling follows Src/Raf/ERK and PI3K/AKT pathways. …”
Get full text
Get full text
-
12
-
13
A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation...
Published 2019“…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …”
Get full text
Get full text
-
14
Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway
Published 2023“…Moreover, the cotreatment of EE 1/1000 or oleuropein with insulin increased considerably the expression of p-IRS, p85-pI3K, and p-AKT. In vivo model, the oral administration of oleuropein at 50 mg/kg in rats fed with high fat diet for 8 weeks reduced inflammation in liver and adipose tissues (WAT), improved glucose intolerance, and decreased hyperinsulinemia. …”
Get full text
Get full text
-
15
-
16
Radiographic assessment of endodontic mishaps in an undergraduate student clinic: a 2-year retrospective study
Published 2022“…Engine-driven rotary instrumentation resulted in a significant decrease in the overall occurrence of instrumentation related endodontic mishaps by 40% compared to hand instrumentation (Odds Ratio = 0.59 [0.36–0.97], p = 0.04). …”
Get full text
Get full text
Get full text
-
17
Comparative Study on Gas-Sensing Properties of 2D (MoS2, WS2)/PANI Nanocomposites-Based Sensor
Published 2022“…In this study, we proposed a new design of an NH3 gas sensor that was comprised of two-dimensional (TMDs, mainly WS2 and MoS2) and PANI. …”
Get full text
Get full text
Get full text
-
18
-
19
Thermodynamic analysis of solar-driven chemical looping steam methane reforming over Cr2O3/Cr redox pair
Published 2019“…For this study, two process configurations are considered: a) CS process - Cr2O3/Cr based MR open process, and b) CSH process- Cr2O3/Cr based MR and WS semi-open process. …”
Get full text
Get full text
-
20
Screening of Qatari Microalgae and Cyanobacteria for Application in CO2 Utilization
Published 2018“…Picochlorum maculatum was found to have the highest lipid and protein content, with 24.0 ± 1.3, 28.0 ± 1.4 and 27.0 ± 1.4 % (w/w) lipids and 21.2 ± 0.2, 23 ± 0.1, and 20 ± 0.9 % (w/w) proteins for cultivation at 30, 35 and 40˚C respectively. …”
Get full text
Get full text