Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells by Posadino, Anna Maria

“…Failure of PE to induce PC3 damage in cells overexpressing Akt further confirms its implication in the PE-elicited cell death. …”
Get full text
Get full text
Get full text

Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines by Prabhu K.S.

“…Treatment with GC suppressed constitutively phosphorylated AKT and downregulated expression of inhibitor of apoptotic proteins XIAP, cIAP-1, and cIAP-2. …”
Get full text
Get full text

Credit bureaus and financial constraints do corruption matter? by Ben Ali, Mohamed Sami

Get full text
Get full text

A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation... by Thirumal Kumar, D

“…We also performed a virtual screening analysis with 19 AKT inhibitors obtained from the Selleck Chemicals website those satisfied the Lipinski rule of 5. …”
Get full text
Get full text

Salvia fruticosa Induces Vasorelaxation in Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway by Anwar, M. Akhtar

“…Furthermore, SF induced Akt phosphorylation as well as increased cGMP levels in rings treated with increasing doses of SF. …”
Get full text
Get full text

Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling by Chung, Jihyun

“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
Get full text
Get full text

Signaling pathways activated by PACAP in MCF-7 breast cancer cells by Zibara, Kazem

“…Moreover, selective inhibition of Src or PI3K resulted in a significant decrease in the phosphorylation of ERK and AKT, but not p38, demonstrating that PACAP signaling follows Src/Raf/ERK and PI3K/AKT pathways. …”
Get full text
Get full text

Preparation of Mesoporous/Microporous MnCo2O4 and Nanocubic MnCr2O4 Using a Single Step Solution Combustion Synthesis for Bifunction Oxygen Electrocatalysis by Ashok, Anchu

Get full text
Get full text

Adaptive thermal comfort in the different buildings of Darjeeling Hills in eastern India – Effect of difference in elevation by Thapa, Samar

“…Whereas, the mean comfort temperature decreased with the elevation of the location and this difference was also statistically significant, t = −92.34 (df = 2607, p < 0.001). …”
Get full text
Get full text

Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway by Hadrich, F.

“…Moreover, the cotreatment of EE 1/1000 or oleuropein with insulin increased considerably the expression of p-IRS, p85-pI3K, and p-AKT. In vivo model, the oral administration of oleuropein at 50 mg/kg in rats fed with high fat diet for 8 weeks reduced inflammation in liver and adipose tissues (WAT), improved glucose intolerance, and decreased hyperinsulinemia. …”
Get full text
Get full text

A Reverse MultipleChoice Based mLearning System by Karkar, AbdelGhani

“…Using a knowledge base, a set of answer choices will be created for a multiple-choice question. …”
Get full text
Get full text

Inner sphere oxidation of N,N′-ethylenebis(isonitrosoacetyleacetoneimine)copper(II) by N-bromosuccinimide in aqueous weakly acidic solutions by Salih, Isam M.

“…The mechanism of the title reaction is consistent with an inner sphere mechanism in which a pre-equilibrium step precedes the electron transfer step. …”
Get full text
Get full text

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach by P., Sneha

“…Missense mutations of the HNF1A were retrieved from public databases and subjected to a three-step computational mutational analysis to identify the underlying mechanism. …”
Get full text
Get full text

A process for CO2 capture and brine salinity reduction through reaction with potassium hydroxide: A multi-stage evaluation by Mourad, Aya A-H.

“…Solvay and modified Solvay processes are facing a major challenge in reducing brine salinity to a level suitable for agriculture and industry. …”
Get full text
Get full text

A decision support system for automating document retrieval and citation screening by van Dinter, Raymon

“…The proposed DSS is effective and can substantially decrease the document retrieval and citation screening steps' workload and error rate. 2021 The Author(s)…”
Get full text
Get full text

Enhanced boron removal by electricity generation in a microbial fuel cell by Ping, Qingyun

“…Two scenarios were examined, the MFC as a pretreatment process and the MFC as a post-treatment step in connection with conventional desalination. …”
Get full text
Get full text

A Framework for Time-Driven Activity-Based Costing for Orthopedic Procedure by Holozada, Bayan Hani

“…This study used method of Time-Driven Activity-Based costing (TDABC) approach to examined cost reduction in healthcare sector, Knee Arthroplasty Department in Al-Emadi Hospital as case-study for delivering a primary knee arthroplasty consultation. The purpose of the study is to propose an optimization model that tends to determine significant and insignificant resources and cost uncertainties in a particular healthcare service. …”
Get full text
Get full text

Preparation and characterization of chemically synthesized polyaniline–polystyrene blends as a carbon dioxide gas sensor by J., Bhadra

“…The SEM results of the above polymerized blends reflect the formation of spherical nanoparticles with diameter ranging from 50nm to 90nm with a decrease in PS concentration that facilitates the formation of clusters. …”
Get full text
Get full text
Get full text

Solar hydrogen production via a samarium oxide-based thermochemical water splitting cycle by Bhosale, Rahul

“…The computational thermodynamic analysis of a samarium oxide-based two-step solar thermochemical water splitting cycle is reported. …”
Get full text
Get full text

Qatar Culture Collection of Microalgae: A Sustainable Source for Biodiesel Production and Omega Fatty Acid Compounds by Bounnit, Touria

“…A one step transesterification process was used to derivitize the intrinsic lipid into fatty acid methyl esters and the individual components were identified against known standards. …”
Get full text
Get full text