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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
Published 2017“…We observed reduction in the number of intermolecular hydrogen bonds, compactness, and electrostatic potential, as well as the loss of salt bridges, in the R203C mutant complex. Substitution of arginine with cysteine at position 203 decreases the affinity of the protein for DNA, thereby destabilizing the protein. …”
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The role of NF-κB and AhR transcription factors in lead-induced lung toxicity in human lung cancer A549 cells.
Published 2019“…However, the link between Pb lung toxicity and NF-κB and/or AhR pathways remains unclear. This study was established to explore the role of NF-κB and AhR modulation in Pb-induced lung toxicity in human lung cancer A549 cells. …”
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A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase
Published 2019“…The mutations occurring in the MGMT protein might result in dysfunction of such DNA repair mechanism. In this study, we attempted to evaluate the impact of six missense mutations (Y114E, Y114A, R128G, R128A, R128K, and C145A) at three active-site positions (Y114, C145, and R128) as this might hinder the DNA binding to the protein. …”
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Biophysical studies of the effect of high power ultrasound on the DNA solution
Published 2014“…The decrease in the dielectric increment indicated a decrease in length of DNA molecule after exposure to ultrasound power.…”
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Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects
Published 2019“…Therefore, the present study provides molecular evidence for a pathway involved in the DNA damage induced by long-term cigarette and waterpipe smoke in human subjects. …”
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Novel potentials of the DPP-4 inhibitor sitagliptin against ischemia-reperfusion (I/R) injury in rat ex-vivo heart model
Published 2018“…The aim of the study was to unveil the unknown and possible cardioprotective targets that can be exerted by sitagliptin (Sitg) against ischemia-reperfusion (I/R) injury. Male wistar rats received 2 weeks? Sitg oral treatment of different doses (25, 50, 100, and 150 mg/kg/day), or saline as a Control. …”
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Adaptive thermal comfort in the different buildings of Darjeeling Hills in eastern India – Effect of difference in elevation
Published 2018“…Whereas, the mean comfort temperature decreased with the elevation of the location and this difference was also statistically significant, t = −92.34 (df = 2607, p < 0.001). …”
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Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanis...
Published 2014“…However, none of these metabolites were shown to be AhR ligands. The induction of CYP1A1 by these metabolites seems to be ligand-independent, possibly through a decrease in HSP90 protein expression levels. …”
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Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach.
Published 2019“…The DNA repair system is crucial to repair the error resulting in DNA replication. …”
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Portfolio Selection Problem Using CVaR Risk Measures Equipped with DEA, PSO, and ICA Algorithms
Published 2022“…It was found that when solving the Mean-CVaR model with evolutionary algorithms, the risk decreased. …”
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Chemical characterization and evaluation of antimicrobial and cutaneous wound healing potentials of gold nanoparticles using Allium saralicum R.M. Fritsch
Published 2020“…FT-IR results offered polysaccharides and protein in A. saralicum were the sources of reducing power, reducing gold ions to AuNPs. …”
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Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Supplementation Alters Gut Microbiome and Corrects Dyslipidemia in Rats.
Published 2019“…Colon digesta were subjected to DNA extraction and subsequent 16S rRNA gene sequencing. …”
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In silico and in vivo models for Qatari-Specific classical homocystinuria as basis for development of novel therapies.
Published 2018“…The p.R336C knock-in HEK293T and HepG2 cells decreased the level of CBS expression and reduce its structural stability; however, treatment of the p.R336C knock-in HEK293T cells with betaine, a chemical chaperone, restored the stability and tetrameric conformation of CBS, but not its activity. …”
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Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptin
Published 2015“…Mitochondria from hyperleptinemic LoxTB MC4R−/− mice kidneys respired NADH-generating substrates (including palmitate) at lower rates due to an apparent decrease in complex I activity, and these mitochondria showed oxidative damage. …”
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