Changes in neural activity were decreased in animals pre-exposed to 5-HT and <i>mod-1</i> mutants when the worms switched their locomotive direction. by Haruka Mori (8082215)

“…(F) Decreasing levels of RID neural activity during the transition periods from forward to backward locomotion in mock, 5-HT pre-exposed (p = 1.3 × 10⁻³), and <i>mod-1</i> mutant (p = 5.4 × 10⁻⁴) animals. …”

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice by Guillaume P. Dugué (620333)

“…<i>In vivo</i>, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons. …”

Table_1_FMT intervention decreases urine 5-HIAA levels: a randomized double-blind controlled study.DOCX by Lihong Wang (14991)

“…However, in the placebo group, GSRS, CARS, and SRS scores showed no significant changes, while ABC scores decreased from 72 to 58.75 (p = 0.034). The FMT group also showed a significant reduction in urinary 5-hydroxyindoleacetic acid (5-HIAA) levels from 8.6 to 7.32 mg/L (p = 0.022), while other metabolites showed no significant changes.…”

Drugs which cluster on the 'anxiolytic' group decrease 5-HT turnover in the brain. by Caio Maximino (100467)

“…<p>(A) Turnover rates, as measured by 5-HIAA:5-HT ratios, normalized to the values of vehicle-treated animals, for the following drugs: fluoxetine (FLX; chronic treatment with 10 mg/kg); chlordiazepoxide (CDZ; 0.02 mg/kg); clonazepam (CLZ; 0.05 mg/kg); diazepam (DZP; 1.25 mg/kg); buspirone (BUS; 50 mg/kg); ethanol (EtOH, 2.5%); dizocilpine (MK; 0.005 mg/kg); verapamil (VER; 5 mg/kg); WAY 100,635 (WAY; 0.03 mg/kg); and SB 224,289 (SB; 2.5 mg/kg). …”

Decreased responsivity to mechanical stimuli during DRN 5-HT neurons photostimulation. by Guillaume P. Dugué (620333)

VAMP2 decreases 5-HT uptake and SERT cell surface expression in HEK-293 MSR cells by reducing the delivery rate of the transporter to the plasma membrane. by Heidi Kaastrup Müller (570207)

Subjects:

Microparticles (MPs) from CD patients decrease 5-HT contraction in mouse aorta. by Daniela Leonetti (447114)

The coefficient of variation of the neural activity, unlike that of velocity, was decreased in animals pre-exposed to 5-HT and <i>mod-1</i> mutants. by Haruka Mori (8082215)

5-HT supplementation inhibits mitophagy. by Li Gao (131516)

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Activation of MAPKs in HCS-2/8 cells treated with 5-HT or agonist of each 5-HT₂ receptor and rescue effect of inhibitors of ERK1/2 and JNK on the BW723C86-decreased CCN2 production. by Ayaka Hori (4597795)

Effect of 5-HTR blockade on error pattern in the work/delay task. by Yukiko Hori (299784)

Subjects:

5-HT₇Dro knock-down decreases frequency of courtship behaviors. by Jaime Becnel (218896)

“…When compared with the parental lines 5-HT₇-Gal4 (Gal4) and UAS-sym-5-HT₇-dsRNA (UAS), the frequency of licking, curling and copulation attempts was significantly decreased. …”

5-HT supplementation induces mitochondrial damage. by Li Gao (131516)

The influence of 5-HT on MSQ43 cells. by Li Gao (131516)

Effect of 5-HT depletion via pCPA on incentive. by Yukiko Hori (299784)

Subjects:

Antagonist dosage and occupancy for each 5-HT receptor subtype. by Yukiko Hori (299784)

Subjects:

<i>patDp</i>/+ mice have decreased tissue 5-HT and increased tissue DA levels during postnatal development. by Kota Tamada (235174)

Decreased expression of 5-HT-specific genes in adult <i>Lmx1b</i> iCKO mice. by Ning-Ning Song (233637)