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Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients
Published 2022“…Platelet counts, on the other hand, dramatically decreased in both IM and (HU + IM). (4) Conclusion: Because the studied genes (BCL2, PP2A, CIP2A, and WT1) are participating in cell proliferation and death, the findings show that the examined genes are significant to understand the efficacy of various therapies. …”
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Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2.
Published 2018“…As the next step, comparative physicochemical changes of the native and the mutant proteins were carried out using essential dynamics. …”
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Inner sphere oxidation of N,N′-ethylenebis(isonitrosoacetyleacetoneimine)copper(II) by N-bromosuccinimide in aqueous weakly acidic solutions
Published 2013“…The value of the observed rate constant, k obs, increases with decreasing pH. At constant reaction conditions, the dependence of the observed rate constants, k obs, is described by Eq. (1). kobs = ko + k1 [H+] The dependence of both kand k 1 on [SBr] is not linear. …”
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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
Published 2017“…Missense mutations of the HNF1A were retrieved from public databases and subjected to a three-step computational mutational analysis to identify the underlying mechanism. …”
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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation...
Published 2019“…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …”
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ELECTRODE SUSPENSION FOR AQUEOUS SODIUM FLOW BATTERY
Published 2022“…At 1.5 wt% KB, the anolytes could tolerate high load (25 wt%) of NTO without severe rise in the rigidity and conductivity under static and flow modes. …”
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Microstructure, wear and corrosion characteristics of Cu matrix reinforced SiC–graphite hybrid composites
Published 2019“…Composite containing 5 wt.% reinforcement has shown minimum wear rate and maximum corrosion resistance. …”
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Impact of aluminium acetate particles size on the gelation kinetics of polyacrylamide-based gels: Rheological and molecular simulation study
Published 2021“…The addition of bentonite at low crosslinker concentrations (0.5–1 wt.%) did not decrease the gel strength of 7 wt.% PAM/1 wt.% AlAc significantly. …”
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A new insight into the separation of oil from oil/water emulsion by Fe3O4?SiO2 nanoparticles
Published 2021“…For the oil recovery process, the Fe3O4 was applied for the inhibition (i.e., decrease) of oil sedimentation, and the SiO2 NPs were applied for wettability alteration and IFT reduction. …”
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Influence of nitrogen doping on the electrocatalytic activity of Ni-incorporated carbon nanofibers toward urea oxidation
Published 2017“…However, the electrochemical measurements indicated that the content of the urea in the initial electrospun solution should be optimized as the results showed that the best nickel surface activation as well as the maximum observed current density can be achieved when the urea content is kept at 5 wt%. Typically, the observed current densities using 1.0 M urea (in 1 M KOH) were 3.15, 29.7, 13.75, 47.55, 14.13 and 9.85 mA/cm2 for the nanofibers obtained from electrospun solutions having 0, 1, 2, 5, 7 and 9 wt% urea, respectively. …”
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Heat stress impairs proprioception but not running mechanics
Published 2019“…Step frequency decreased (−2.5 ± 3.6%) and step length increased (+2.6 ± 3.8%) over time (p < 0.05), independently of condition. …”
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Experimental investigation on the compressibility of Al/Al2O3 nanocomposites
Published 2016“…With up to 12 wt.% of Al2O3, microhardness increases from 62 to 150 HV due to the decrease of the crystallite size. …”
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The status of forward osmosis technology implementation
Published 2019“…The outcomes of 15 studies conducted at pilot scale revealed the energy associated with the draw solution (DS) recovery to present a significant barrier to implementation of the technology, with a 40–50% decrease in energy consumption required for the DS recovery step for the process to successfully compete with classical reverse osmosis (RO) based processes. …”
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Solar Thermochemical Hydrogen Production via Terbium Oxide Based Redox Reactions
Published 2016“…The 1st step of the Tb-WS cycle involves thermal reduction of TbO2 into Tb and O2, whereas the 2nd step corresponds to the production of H2 through Tb oxidation by water splitting reaction. …”
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Thermal characterization of phase change materials based on linear low-density polyethylene, paraffin wax and expanded graphite
Published 2016“…A similar decrease in sensible heat with increased loading of EG was observed for PCMs containing 50 wt.% of EG. …”
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Effects of superelastic nano-NiTi additions on electroless Ni –P coating properties under bending
Published 2019“…In this study, electroless Ni –P-nano-NiTi composite coatings containing 5.14 wt%, 6.07 wt%, and 7.02 wt % NiTi were subjected to three-point bend testing in order to determine bending properties. …”
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Evacuation under flooded conditions: Experimental investigation of the influence of water depth on walking behaviors
Published 2021“…Characteristics of individual walking trajectories were also investigated, and it was identified that the average step frequency for walking in water was significantly lower than that for walking under normal, i.e., without water, conditions. …”
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