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The rate of lariat formation is decreased two-fold by isoginkgetin treatment.
Published 2014“…The indicated values are from an average of three biological replicates, and <i>p</i>-values are from two-tailed <i>t</i>-tests based on mean values for aggregated introns 2–10 (n = 9). (<b>C</b>) Isoginkgetin treatment leads to a decreased rate of lariat formation (* indicates <i>p</i> = 0.02) without affecting exon ligation or excised lariat degradation (<i>p</i> = 0.22, 0.08), with calculations as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0089673#pone-0089673-g001" target="_blank">Fig. 1</a>. …”
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TUDCA decreases ER stress in HOX neonatal rat lungs.
Published 2022“…<p>(<b>A</b>) The expression levels of ER stress markers (P-PERK 0.6±0.1-fold, p<0.001, n = 5; PERK 0.7±0.1-fold, p = 0.00364, n = 5; P-IRE1α 0.6±0.0-fold, p<0.001, n = 5; IRE1α 0.6±0.1-fold, p<0.001, n = 5; GRP78 0.8±0.1-fold, p<0.001, n = 5; cleaved ATF6 0.1±0.0-fold, p<0.001, n = 5; spliced XBP1 0.3±0.0-fold, p<0.001, n = 5; 2 males and 3 females) are all decreased while the N-glycosylated VEGFR2 is increased (3.5±0.2-fold, p<0.001, n = 5) in HOX neonatal lungs at P10 indicating TUDCA can attenuate hyperoxia-induced ER stress. …”
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Beta-catenin signaling is decreased in intermediate progenitor cells.
Published 2010“…Using comparative C<sub>T</sub> analysis with Actin as an endogenous control, real-time PCR showed that Axin2 transcript was 9.55±1.21 fold higher in the Tbr2- cells than in the Tbr+ cells. n = 3. …”
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Resveratrol decreases PKM2 expression.
Published 2013“…<p>Resveratrol treatment decreases PKM2 mRNA in (A), HeLa; (B), HepG2 and (C), MCF-7; by approximately two-folds. β-actin was taken as endogenous control and normalized to PKM2 mRNA. …”
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Hepatic Expression of Detoxification Enzymes Is Decreased in Human Obstructive Cholestasis Due to Gallstone Biliary Obstruction
Published 2015“…</p><p>Conclusions</p><p>The levels of hepatic detoxification enzymes were significantly decreased in human obstructive cholestasis, and these decreases were positively associated with a marked reduction of FXR levels. …”
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Decreased oscillatory flow decreases <i>klf2a</i> expression.
Published 2009“…(G) <i>klf2a</i> expression decreases after 15-h lidocaine treatment (90%, <i>n</i> = 67). …”
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Relationship between Differential Hepatic microRNA Expression and Decreased Hepatic Cytochrome P450 3A Activity in Cirrhosis
Published 2013“…In this study, we examined if certain microRNAs (miRNA) are associated with decreased hepatic CYP3A activity in cirrhosis.</p> <p>Methods</p><p>Hepatic CYP3A activity and miRNA microarray expression profiles were measured in cirrhotic (n=28) and normal (n=12) liver tissue. …”
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Decreased macrophage recruitment correlates with decreased angiogenesis.
Published 2013“…<p>A) Quantification of BrdU incorporation demonstrates that decreased macrophage infiltration does not significantly correlate with a change in epithelial cell proliferation (N.S. = not significant). …”
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