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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Breaking the barriers towards large-scale microalgae-based bio-hydrogen production
منشور في 2025"…Results showed that cultivation dominates the process cost: typical biomass costs are $3.54–$5.78/kg in tubular PBRs versus $3.42–$4.13/kg in ORPs; an automation/modularization case decreased microalgae production cost from $89 to $16/kg at ∼200 t/yr. …"
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
منشور في 2021"…The problem is modelled using a mixed integer program (MIP) in which the charging time of an EB is pertinent to the battery’s state-of-charge level. To be able to solve large problem instances corresponding to real-world applications of the model, a metaheuristic approach is investigated. …"
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Cost-benefit analysis of antimicrobial stewardship program in a cancer setting in Qatar
منشور في 2024"…Cost avoidance was the expenses saved due to decreased hospital stays and fewer adverse drug events (ADEs). …"
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Cost-Benefit Analysis of Antimicrobial Stewardship Program in the Adult General Medicine Setting in Qatar
منشور في 2024"…</p><h3> Results</h3><p dir="ltr">The operational costs of the program decreased with maturity by cost savings of QAR125 per 100-patient beds per year. …"
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The cost associated with the development of the antimicrobial stewardship program in the adult general medicine setting in Qatar
منشور في 2024"…</p><h3>Results</h3><p dir="ltr">A total of 500 patients were included in the study. The operational costs decreased with the developed ASP. Whereas antimicrobial consumption and resource utilisation, and their associated costs, appear to have declined with the developed ASP, with a cost saving of QAR458 (US$125) per 100-patient beds, the avoided cost was negative, by QAR4,807 (US$1,317) per 100-patient beds, adding to a total QAR4,224 (US$1,160) increase in the 100-patient beds cost after ASP development.…"
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The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in <i>Drosophila melanogaster</i>
منشور في 2023"…One such gene is the single-stranded DNA-binding protein 3 (<i>SSBP3</i>) and its Drosophila melanogaster ortholog is called sequence-specific single-stranded DNA-binding protein (<i>Ssdp</i>). …"
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The cost-benefit associated with the maturity of the Antimicrobial Stewardship Program versus prematurity in Heart Hospital of Hamad Medical Corporation in Qatar
منشور في 2023"…</p><h3>Results</h3><p dir="ltr">A total of 668 patients were included in the study (255 in P-ASP versus 413 in M-ASP). With M-ASP, cost of hospital tests use ‘decreased’ by QAR 1,149 per 100-patient beds per year, cost of ASP personnel ‘decreased’ by QAR 125 per 100-patient beds with the M-ASP, cost of drug use ‘increased’ by QAR 176,848 per 100-patient beds, cost of resistance and hospitalization ‘increased’ by QAR 216,279 per 100-patient beds per year. …"
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The investigation of treatment design parameters on carbon integration networks
منشور في 2023"…As a result, this paper focuses on reassessing the performance of carbon integration networks using a more rigorous cost model for the treatment design stage. The effect of utilizing different treatment operating conditions on the overall cost of the treatment stage of CO<sub>2 </sub>(before allocation) is first captured using a detailed cost model. …"
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Infliximab versus ciclosporin in steroid resistant acute severe ulcerative colitis: a model-based cost-utility analysis of data from CONSTRUCT pragmatic trial
منشور في 2023"…<h3>Background</h3><p dir="ltr">There is limited evidence in the literature on the long-term effectiveness and cost-effectiveness of treatments for Acute Severe Ulcerative Colitis (ASUC). …"
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An efficient claim management assurance system using EPC contract based on improved monarch butterfly optimization models
منشور في 2024"…Conventional construction models typically optimize only a single objective, such as time, cost, or delay, which may not effectively enhance overall performance. …"
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Coalition game theoretic P2P trading in a distribution network integrity-ensured local energy market
منشور في 2023"…The simulation results confirm that participants, both sellers and purchasers, can decrease their energy costs substantially, and the LEM operator can also secure its margin while the distribution network voltages and line congestion are within the prescribed ranges.…"
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Operation optimization of propane pre-cooled mixed refrigerant LNG Process: A novel integration of knowledge-based and constrained Bayesian optimization approaches
منشور في 2024"…In addition, the optimized SEC in this study is 14.5 % to 38.6 % lower than those reported in the literature. At large-scale LNG production (10,000 tons per day), the reduction in the SEC is translated into an 18 MW decrease in compression power, saving approximately 4.7 million $ per year for each C3MR train. …"
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COVID-19 biomarkers for severity mapped to polycystic ovary syndrome
منشور في 2020"…<p dir="ltr">Large scale multi-omics analysis has identified significant differences in the biomarkers between COVID-19 disease and control subjects [1]. …"
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Enhancing the production of biogas through anaerobic co-digestion of agricultural waste and chemical pre-treatments
منشور في 2020"…<p dir="ltr">Large amounts of agricultural solid wastes (ASWs) and animal dung are produced annually causing serious environmental problem that requires proper treatment. …"
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Optimal Energy Dispatch Engine for PV-DG-ESS Hybrid Power Plants Considering Battery Degradation and Carbon Emissions
منشور في 2023"…The system was evaluated against a heuristic control model and a multistage stochastic control model, with the daily overall electricity and carbon emission costs as evaluation metrics. The test results revealed a 9.2% and 3.5% decrease in daily costs compared to the heuristic and stochastic methods, respectively, and a 29.4% decrease in carbon emission costs.…"
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BRET-based biosensors for SARS-CoV-2 oligonucleotide detection
منشور في 2024"…To address this need, as a proof-of-principle study, we engineered a prototype—the versatile, sensitive, rapid, and cost-effective bioluminescence resonance energy transfer (BRET)-based biosensor for oligonucleotide detection (BioOD). …"
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Grid integration of renewable energy in Qatar: Potentials and limitations
منشور في 2021"…The results show that large-scale installations of renewable energy technologies can decrease the emission rate from electricity production at a relatively lower cost. …"