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Spatial information is significantly decreased in dCA1 and vCA1 in APP/PS1 mice.
Published 2024“…Histograms show the mean firing rate for the corresponding neuron along each segment of the virtual track. (B) In dCA1, spatial information was decreased in APP/PS1 mice relative to C57BL/6 controls (mean ± std: C57BL/6 = 0.132 ± 0.048, APP/PS1 = 0.128 ± 0.051, p < 0.005, two-sided Wilcoxon rank-sum test, n<sub>C57BL/6</sub> = 305 units from 5 recording sessions, n<sub>APP/PS1</sub> = 180 units from 4 recording sessions). …”
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Spatial information of excitatory neurons in APP/PS1 mice are decreased in dCA1 and vCA1.
Published 2024“…(B) In vCA1, spatial information was decreased in APP/PS1 mice relative to C57BL/6 controls (mean ± std: C57BL/6 = 0.143 ± 0.069, APP/PS1 = 0.115 ± 0.039, p < 10<sup>−6</sup>, two-sided Wilcoxon rank-sum test, n<sub>C57BL/6</sub> = 450 units from 6 recording sessions, n<sub>APP/PS1</sub> = 394 units from 8 recording sessions). …”
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