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Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades
Published 2022“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC<sub>50</sub> value of 61 nM compared to that of Tamoxifen (IC<sub>50</sub> value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. …”
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145
Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades
Published 2022“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC<sub>50</sub> value of 61 nM compared to that of Tamoxifen (IC<sub>50</sub> value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. …”
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Capsaicin, pyridoxine, vincristine sulfate and ionomycin significantly decreased axon length ratio but only pyridoxine had no impact on neurotoxicity.
Published 2024“…At a lower dose, 1 nM Vcr caused slow axonal dieback in female rat DRGs but did not impact male rat DRGs. …”
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148
Adaptation to cool temperature decreases basal and stimulated lipolysis and increases <i>de novo</i> lipogenesis and TAG synthesis.
Published 2021“…<p>(<b>A, B</b>) Adipocytes were treated with 10 μM forskolin or 2 μM CL-316,243 (CL) for 6 hours and secretion of glycerol (<b>A</b>) and NEFA (<b>B</b>) measured (<i>n</i> = 4). …”
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Decreased clonogenic capacity of U87MG and U251MG glioma cells dependent on SHG-44 concentration.
Published 2025“…<b>(B)</b> A significant decrease in the proliferative clonal capacity of U251MG colonies was observed with 50ΜM and 100ΜM SHG-44 treatment. …”
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150
Decreased phosphorylation of EIF2α underlies the impairment of arsenite-induced SG formation in LSM12-depleted cells.
Published 2020“…Relative levels of EIF2α phosphorylation were calculated by normalizing the ratio of phospho-EIF2α to EIF2α protein levels per condition to that in control cells with no chemical treatment. Data represent means ± SEM (<i>n</i> = 3). n.s., not significant; *<i>P</i> < 0.05, **<i>P</i> < 0.01, as determined by Student <i>t</i> test. …”
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Table 1_A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity.xls
Published 2025“…Background and Purpose<p>Nicotinic acetylcholine receptors (nAChRs), which are expressed throughout the mammalian brain, mediate a variety of physiological functions. …”
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Juvenile demyelination leads to a substantial decrease in potassium currents in PV interneurons of the PFC.
Published 2025“…Scale: 500 pA, 100 ms. <b>B</b>. I–V curves showing a significant decrease in Kv amplitude in PV interneurons from mice that underwent juvenile demyelination. …”
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Scatter plot for the absolute decrease in CS rates (A) and the relative decrease in CS rates (B) from 2008 to 2016 among hospitals in Guangzhou grouped by their baseline CS rates.
Published 2019“…One circle represents one hospital, with blue (<i>n</i> = 20), green (<i>n</i> = 36), orange (<i>n</i> = 34), and purple (<i>n</i> = 22) representing baseline CS rates of <30%, 30%–39%, 40%–49%, and ≥50%, respectively. …”