Chronic colitis induces marked changes in protein expression in the adult heart and blood. by Yanbo Tang (11457519)

The proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases in <i>APC</i>-mutant colon tissues from FAP patients. by Tao Zhang (43681)

“…Results show that, in normal crypts, the distribution and proportion of cells staining for ALDH1 and CGA are very similar. In contrast, in <i>APC</i>-mutant tissues from FAP patients, the proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases. …”

The parameters of gas exchange markedly decreased in maize <i>zmstomagen1/2</i> mutant compared with in wild type (WT). by Juan-Juan Xu (18590868)

Expression of lipid biosynthetic genes is decreased with polyamine depletion. by Yazmin E. Cruz-Pulido (20285238)

Withdrawal of Type I JAKinibs increased STAT phosphorylation, a phenomenon present but markedly lower in Type II JAKinibs. by Ilya Gurevic (1326786)

3D interactions between the ligand and the protein_DNA complex in the first (C1) and second (C2) clusters. by Ahmed A. Gaber (13302308)

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Region-specific gain and loss of repressive marks in aged somatic tissues. by Cheng-Lin Li (3620321)

De-repression of gene expression and responsive histone marks. by Dana Lau-Corona (8861900)

“…(<b>C</b>) Shown at the right are 8 different combinations of histone mark changes, one of which was assigned to each E1/E2-KO-responsive gene based on whether there was a decrease in H3K27me3 marks at either the gene body or promoter region, and/or an induction of H3K27ac marks or of H3K4me1 marks, as determined by GREAT analysis (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008796#sec012" target="_blank">Methods</a>). …”

Group-level narrow- and broad-band spectral changes after hemispherotomy reveal a marked EEG slowing of the isolated cortex, robust across patients. by Michele Angelo Colombo (22446342)

S1 File - by Hongyu Li (1332669)

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Narrow- and broad-band spectral changes after hemispherotomy in an awake representative patient, displaying marked electroencephalography (EEG) slowing of the isolated cortex. by Michele Angelo Colombo (22446342)

“…In the middle panel, the topographies of Slow Delta Power, indexing the power spectral density (PSD) of low-frequency activity (0.5–2 Hz, hereby estimated under average reference for display purposes), show a marked inter-hemispheric asymmetry post-surgery. <b>(C)</b> The EEG PSD, averaged by geometric mean across intrahemispheric bipolar derivations, reveal an increase of slow frequency activity (<2 Hz) and a broad-band steepening of the PSD over the disconnected hemisphere post-surgery, which is evidenced in the inset graph by the linear fit of the PSD under double logarithmic axes (power-law fit). …”

Persistence of β-cell responsiveness for over two years in autoantibody-positive children with marked metabolic impairment at screening by Emily K. Sims (5278130)

“…</p> <p><strong>Results:</strong> Longitudinal analyses revealed annualized AUC C-peptide increases in non-progressors vs. decreases in progressors (p≤0.026 for DPT-1 and TNPTP). …”

<i>RTTN</i>-mutated organoids exhibit decreased proliferation and increased cell death at early stages. by Justine Guguin (9088672)

Deletion of microglial NKCC1 markedly impacts on baseline cell morphology and alters transformation to reactive microglia. by Krisztina Tóth (12009827)

“…(<b>D, E)</b> NKCC1 protein expression in a large number of randomly sampled NKCC1 KO microglia cells is markedly reduced compared to WT cells. …”

Pericentric heterochromatin structural integrity is disrupted in the absence of CFDP1 due to loss of core heterochromatin protein, HP1α and H3K9me3 marks. by Gokul Gopinathan (7930679)

HSV-1 increases <i>de novo</i> lipogenesis. by Camilla Albano (16446679)

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Impact of CMS121 and C75 on HSV-1 entry into Vero cells. by Camilla Albano (16446679)

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CMS121 and C75 reduce the infectivity of HSV-1 viral particles. by Camilla Albano (16446679)

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Cinacalcet administered early in the inactive phase markedly decrease parathyroid Ki-67 index. by Søren Egstrand (10906087)

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The heart rate was similar among the groups. by Hongyu Li (1332669)

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