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Autophagy Mediates the Effects of Physical Exercise on Learning and Memory through Activation of Hippocampal BDNF
Published 2020“…These positive outcomes are mediated through the induction of the expression of a growth factor, brain derived neurotrophic factor (BDNF), in the hippocampus. …”
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22
Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal
Published 2019“…MG was increased in high glucose by increased flux of MG formation linked to increased glucose metabolism mediated by proteolytic stabilisation and increase of hexokinase-2 (HK-2); later potentiated by proteolytic down regulation of glyoxalase 1 (Glo1) - the major enzyme of MG metabolism. …”
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Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
Published 2019“…We also found increased levels of LAMP-1 and LAMP-2A both <i>in vitro</i> and <i>in vivo</i>, along with decreased levels of α-synuclein. Moreover, DHM and Sal B treatments exhibited anti-inflammatory activities, preventing astroglia- and microglia-mediated neuroinflammation in BAC-α-syn-GFP transgenic mice.…”
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Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death
Published 2023“…Scavenging ROS using NAC significantly decreases cell death but has minimal effect on autophagy activation, suggesting that the accumulation of ROS is downstream of autophagy activation but upstream of cell death. …”
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25
Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats
Published 2020“…The purpose of this study is to evaluate and compare the protective effect of oleuropein- and hydroxytyrosol-rich extracts, derived from olive leaves, on high-fat diet-induced lipid metabolism disturbance and liver injury in rats. …”
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The mediating effect of corporate social responsibility on the relationship between corporate governance and financial performance. (c2016)
Published 2016“…In particular, this study explores the possible mediating effect of CSR on the aforementioned relationship. …”
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Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
Published 2021“…Purpose Establishing the reliability of a new method to check the mean retinal and choroidal reflectivity and using it to find retinal and choroid changes in amblyopia. …”
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Hypoxic Stress Induces Complement-Mediated Lysis of Mesenchymal Stem Cells by Downregulating Factor H and CD59
Published 2024“…Mesenchymal stem cells (MSCs) secrete Factor H and express CD59 to protect themselves from complement-mediated damage. Severe hypoxia found to decrease the survival chances of MSCs after transplantation; however, little is known about the impact of severe hypoxia on modulating the complement system activity and its effect on MSCs survival. …”
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Influence of temperature on tire-pavement noise in hot climates: Qatar case
Published 2021“…There is an apparent trend of decreasing temperature coefficient with increasing mean texture depth of dense graded asphalt pavements. …”
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Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity
Published 2023“…Individually, both valine (245 ± 33 to 105 ± 23 µmol/L; p < 0.0001), and leucine (130 ± 20 to 75 ± 13 µmol/L; p < 0.05), decreased significantly in response to the BCAA-restricted diet. …”
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Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans
Published 2021“…Three of these compounds also decreased α-synuclein oligomers in mammalian neurons, including rifabutin which has not been previously investigated for Parkinson’s disease. …”
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Can Geneva Survive Astana?
Published 2022“…By the initiation of the Astana process, the UN lost its monopoly in peacemaking, and its legitimacy as a mediator started to decrease gradually. Eventually, the UN's peacemaking in Syria became paralyzed, and UN mediation passed the point of credibility. …”
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Resveratrol-Elicited PKC Inhibition Counteracts NOX-Mediated Endothelial to Mesenchymal Transition in Human Retinal Endothelial Cells Exposed to High Glucose
Published 2021“…<p dir="ltr">Diabetes-associated long-term hyperglycaemia leads to oxidative stress-mediated fibrosis in different tissues and organs. …”
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Human Recombinant Arginase I (Co)-PEG5000-Induced Arginine Depletion of Breast Cancer Cell Lines Causes Autophagy Mediated Cell Death
Published 2024“…In this study, we showed for the first time that arginine deprivation induced by a recombinant human arginase drug induces selective cytotoxicity mediated by autophagy in distinct human breast cancer cell lines. …”
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ROS-Mediated Autophagic Death in Glioblastoma Cells Upon Treatment by Human Recombinant Arginase I (Co)- PEG5000 [HuArgI (Co)-PEG5000]
Published 2021“…Addition of N-acetyl-cysteine (NAC); being a reactive oxygen species (ROS) scavenger, led to a significant decrease in the cytotoxicity of arginine deprivation to U251 and A172 cells, indicating that ROS generation reversed the cytotoxicity of arginine deprivation to GBM cells. …”
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masterThesis
