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Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1
منشور في 2015"…CD34+ bone marrow blasts and peripheral blood mononuclear cells lacked uPAR expression and were resistant to PrAgU2/LF, demonstrating the lack of toxicity to normal hematological cells and, therefore, the tumor selectivity of this approach. Dose escalation in mice revealed that the maximal tolerated dose of PrAgU2/LF is at least 5.7-fold higher than that of the wild-type anthrax lethal toxin, PrAg/LF, further demonstrating the increased safety of this molecule. …"
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123
Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity
منشور في 2025"…</p><h3 dir="ltr">Methods</h3><p dir="ltr">Adult male Balb/c mice received daily intraperitoneal injections of various doses of AB-FUBINACA (0.75, 1.5, and 3 mg/kg for 3 weeks). …"
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Performance assessment of an integrated absorption cooling-hydrogen liquefaction system using geothermal energy
منشور في 2013"…The results show that the mass of hydrogen gas pre-cooled by the absorption system per unit mass flow rate of geothermal water flowing through the system (n) and the amount of hydrogen liquefied per unit mass flow rate of geothermal water flowing through the system (y) increase with an increase in the geothermal source temperature. …"
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125
Inappropriate Medication Use in Elderly Lebanese Outpatients
منشور في 2006"…Beers’ criteria, duplicate therapy, indication, dose, dose frequency including missing doses, duration and discontinuation of therapy, adverse effects, drug-drug and/or drug-disease interactions, and poor memory). …"
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126
Comparative Efficacy and Safety of Intravenous Vasopressors in Pre-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis
منشور في 2025"…Fewer patients treated with epinephrine achieved favorable neurological outcomes (OR: 0.70, p=0.005). High-dose epinephrine (HDE) improved ROSC (OR: 1.19, p=0.003) and SHA (OR: 1.20, p=0.04) over standard-dose epinephrine (SDE) but not SHD or neurological outcomes. …"
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127
The Anti-Proliferative and Pro-apoptotic Effect of Topotecan in Combination With Thymoquinone in Acute Myelogenous Leukemia
منشور في 2014"…Topotecan (a novel topoisomerase I inhibitor and a water-soluble camptothecin analog) is active against numerous human tumor cell lines, and has shown promising antineoplastic activity in solid tumors and acute leukemia. Due to the primary dose-limiting toxicity of topotecan which is myelosuppression, it is necessary to identify other chemotherapeutic agents that can work synergistically with topotecan, potentially increasing its efficacy while limiting its toxicity. …"
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128
MRP4
منشور في 2011"…Stimulation of WT and MRP4 KO mice by increasing concentrations of isoproterenol (ISO: 0.1μg/kg to 3 mg/kg) induced dose-dependent positive inotropic and chronotropic effects but there was no difference in the rate of contraction (Vmax: 11214 ± 682 in WT vs 10697 ± 691 in KO) or in the heart rate (724 ± 21 in WT vs 711 ± 21 in KO) between both groups. …"
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129
An improved non-dimensional model of wet-cooling towers
منشور في 2020"…The first method shows a maximum decrease of 4.4 per cent in error, whereas in the second method, the maximum error was found to be 3.3 and 6.8 per cent when the inlet air was unsaturated and saturated, respectively. …"
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130
Cryomyolysis, a new procedure for the conservative treatment of uterine fibroids
منشور في 1998"…Normal uterine volume ranged from 35.6 to 548.7 ml preoperatively and 45.1 to 729.6 ml postoperatively (mean increase 40%); however, myoma volume showed a mean decrease of 6% (range-87-28%). …"
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131
Syncope following Pfizer BioNTech (bnt162b2) vaccination unmasking Brugada syndrome
منشور في 2023"…<p>The Brugada syndrome is an uncommon inherited condition associated with increased risk of ventricular tachyarrhythmias and sudden cardiac death. …"
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SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study
منشور في 2023"…Risk of infection varied minimally by age and sex but increased significantly with coexisting conditions. …"
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134
The potential impact data of Tylosin and Enrofloxacin veterinary antibiotics on germination and accumulation in barley seed as a forage crop and good dietary sources using LC/MS-MS
منشور في 2019"…The germination percentage was significantly inhibited with the increasing Enrofloxacin dose concentrations, while, it was to some extent on the contrary in the case of Tylosin, where seed germination was enhanced as a result of increasing Tylosin concentrations.Liquid chromatography-tandem mass spectrometry LC/MS-MS was used to detect and quantify the uptake dosage after drying and extracting the antibiotic compounds from the seedling.…"
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135
Emerging therapies in multiple myeloma
منشور في 2015"…The treatment of multiple myeloma has evolved significantly over the past 2 decades due to the use of high-dose chemotherapy and autologous stem cell transplantation, and the subsequent introduction of the immunomodulatory agents (thalidomide and lenalidomide) and the proteasome inhibitor (bortezomib). …"
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136
Produced Water Treatment Using Naturally Abundant Pomegranate Peel
منشور في 2016"…The optimum parameters for oil removal were: pH 9.5, adsorbent dose = 2.33 g/L, contact time = 50.0 min, and adsorption temperature = 55.0°C. …"
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137
Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis
منشور في 2021"…TAVR was associated with 37% (95% CI [0.51–0.78) mean RR reduction of post-procedural PPM, a decrease that was not affected by the surgical risk at inclusion, neither by the transcatheter heart valve system. …"
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Sequential therapy in patients receiving Fluoroquinolones at the American University of Beirut Medical Center. (c2001)
منشور في 2001"…Date of switch (if applicable), oral antibiotic chosen, mean time to switch, mean hospital duration, and mean treatment duration were also recorded. …"
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Hyper-Hypo study: A Retrospective Observational Study of Neonatal Hypoglycemia Related to Maternal Hypertension
منشور في 2023"…However, a sub-group comparison of neonates (with initial blood glucose <2.6 mmol/L) showed methyldopa to be marginally associated with a 2 mmol/L decrease from the mean initial blood glucose, mean 1.6 ± 0.5 mmol/L, and methyldopa (1.4 ± 0.5 mmol/L; p= .045). …"