DataSheet_1_Impact of endometrial compaction on reproductive outcomes after cryotransfer of euploid embryos in a modified natural cycle: protocol for a prospective cohort study.pdf by Esperanza De la Torre Perez (17363236)

“…Inclusion criteria are: 18 to 50 years of age, with primary or secondary infertility, subjected to endometrial preparation in a modified natural cycle for transfer of a genetically euploid blastocyst, from their own oocyte or oocyte donation, with a normal uterine cavity. …”

Both monosomies and trisomies decrease cellular fitness. by Dorine C. Hintzen (12988183)

Table_2_A Novel Predictive Model to Estimate the Number of Mature Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertili... by Sandro C. Esteves (5143712)

“…The estimated predicted probabilities of a mature oocyte turn into a euploid blastocyst decreased progressively with female age and was negatively modulated overall by use of testicular sperm across age (p < 0.001). …”

Table_1_A Novel Predictive Model to Estimate the Number of Mature Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertili... by Sandro C. Esteves (5143712)

“…The estimated predicted probabilities of a mature oocyte turn into a euploid blastocyst decreased progressively with female age and was negatively modulated overall by use of testicular sperm across age (p < 0.001). …”

Table_3_A Novel Predictive Model to Estimate the Number of Mature Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertili... by Sandro C. Esteves (5143712)

“…The estimated predicted probabilities of a mature oocyte turn into a euploid blastocyst decreased progressively with female age and was negatively modulated overall by use of testicular sperm across age (p < 0.001). …”

Data_Sheet_1_A Novel Predictive Model to Estimate the Number of Mature Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fe... by Sandro C. Esteves (5143712)

“…The estimated predicted probabilities of a mature oocyte turn into a euploid blastocyst decreased progressively with female age and was negatively modulated overall by use of testicular sperm across age (p < 0.001). …”

Table1_Mitochondrial DNA mutations can influence the post-implantation development of human mosaic embryos.xlsx by Akifumi Ijuin (16817115)

“…We hypothesized that mitochondrial function, one of the most critical factors for embryonic development, can influence human post-implantation embryonic development, including a decrease of aneuploid cells in mosaic embryos.…”

Table5_Mitochondrial DNA mutations can influence the post-implantation development of human mosaic embryos.DOCX by Akifumi Ijuin (16817115)

“…We hypothesized that mitochondrial function, one of the most critical factors for embryonic development, can influence human post-implantation embryonic development, including a decrease of aneuploid cells in mosaic embryos.…”

MtDNA replacement in human oocytes with MRR-SCCT procedure. by Xiaoyu Liao (8161995)

MtDNA residual levels and chromosomal copy numbers in mouse SCC transferred blastocysts. by Xiaoyu Liao (8161995)

MtDNA carryover removal and SCC integraty by MRR manipulation in mouse oocytes. by Xiaoyu Liao (8161995)

Image_1_Neuronal Cell-Intrinsic Defects in Mouse Models of Down Syndrome.tif by Alessandra Maria Adelaide Chiotto (7482065)

“…Conversely, our analysis highlighted differences between trisomic and euploid neurons in terms of reduction of spine density, in accordance with in vivo data obtained by other groups, proposing the presence of a cell-intrinsic malfunction. …”

Whole genome sequencing analysis of FLC-evolved and engineered strains. by Xin Zhou (54275)

Trisomy detection accuracy of tested NIPT software tools across different sequencing depths. by Priit Paluoja (6927959)

SNARE proteins rescue impaired autophagic flux in Down syndrome by Stefanos Aivazidis (3944795)

“…Collectively, our results indicate that impaired autophagic clearance is a characteristic of DS cells that can be reversed by enhancement of SNARE protein expression and provides further evidence that PN disruption represents a candidate mechanism for multiple aspects of pathogenesis in DS and a possible future target for therapeutic intervention.…”

Virtual-Partition Digital PCR for High-Precision Chromosomal Counting Applications by Lucien Jacky (10197624)

“…Each physical partition is then divided into a series of virtual partitions, and the resulting increase in partition count substantially decreases partitioning error. …”

Genome instability in STRIPAK complex mutants. by Patricia P. Peterson (20291306)

“…The WT/WT genome is euploid, while <i>PPH22/pph22</i>Δ and <i>MOB3/mob3</i>Δ strains exhibit multiple instances of segmental and whole chromosome aneuploidy, with dark blue and orange highlighting regions/chromosomes with increased and decreased read depth, respectively. …”

Image1_Preimplantation genetic testing for complex chromosomal rearrangements: clinical outcomes and potential risk factors.PDF by Dun Liu (674970)

“…Type B exhibited the lowest rate of euploid embryos at only 6.7%, followed by type A at 11.6% and type C at 14.0%, although the differences were not significant (p = 0.182). …”

Table1_Preimplantation genetic testing for complex chromosomal rearrangements: clinical outcomes and potential risk factors.PDF by Dun Liu (674970)

“…Type B exhibited the lowest rate of euploid embryos at only 6.7%, followed by type A at 11.6% and type C at 14.0%, although the differences were not significant (p = 0.182). …”

Table_7_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx by Beatrice Vione (10734998)

“…</p>Results<p>Results highlight specific alterations of THF with a median concentration ratio DS/control of 2:3, a decrease of a necessary molecule perfectly consistent with a chromosomal dosage effect. …”