Lamina propria dendritic cells, neutrophils, and macrophages produce IL-12p40 in the absence of MyD88 during <i>T</i>. <i>gondii</i> infection. حسب Lindsay M. Snyder (4975163)

SNARE proteins rescue impaired autophagic flux in Down syndrome حسب Stefanos Aivazidis (3944795)

"…Based on our previous observations of PN disruption in DS, we investigated possible dysfunction of the autophagic machinery in human DS fibroblasts and other DS cell models. Following induction of autophagy by serum starvation, DS fibroblasts displayed impaired autophagic flux indicated by autophagolysosome accumulation and elevated p62, NBR1, and LC3-II abundance, compared to age- and sex-matched, euploid (CTL) fibroblasts. …"

Virtual-Partition Digital PCR for High-Precision Chromosomal Counting Applications حسب Lucien Jacky (10197624)

"…This demonstration assaytested on 432 samples contrived from sheared cell-line DNA at multiple input concentrations and simulated fractions of euploid or trisomy-21 “fetal” DNAis analyzed using both traditional dPCR thresholding and VPdPCR. …"

Genome instability in STRIPAK complex mutants. حسب Patricia P. Peterson (20291306)

"…<p>(A) Read depth analyses from whole-genome sequencing of the WT/WT (CnLC6683) parental diploid strain and heterozygous mutant diploid strains. The WT/WT genome is euploid, while <i>PPH22/pph22</i>Δ and <i>MOB3/mob3</i>Δ strains exhibit multiple instances of segmental and whole chromosome aneuploidy, with dark blue and orange highlighting regions/chromosomes with increased and decreased read depth, respectively. …"

DataSheet_1_TREM2 is associated with tumor immunity and implies poor prognosis in glioma.docx حسب Mingchen Yu (11807669)

"…<p>Triggering receptor expressed on myeloid cells 2 (TREM2) is expressed in myeloid cells of the central nervous system (CNS), which mediate the immunological response in a variety of diseases. …"

DataSheet_1_Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors.docx حسب Siddhi N. Paudel (18877030)

"…Additionally, targeting myeloid cells with the myelomodulatory therapy trabectedin, a small molecule activator of caspase-8 dependent apoptosis, augmented the survival benefit of T-VEC in a less immunogenic MPNST model. …"

DataSheet_1_Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors.docx حسب Siddhi N. Paudel (18877030)

"…Additionally, targeting myeloid cells with the myelomodulatory therapy trabectedin, a small molecule activator of caspase-8 dependent apoptosis, augmented the survival benefit of T-VEC in a less immunogenic MPNST model. …"

Supplementary Tables S1 and S2 حسب Thomas Clanton (9323303)

"…Here we tested the LPS-responsiveness of mouse soleus when a critical toll receptor adapter protein, (Myd88) was knocked out of all myeloid-derived cells (largely resident macrophages). …"

DataSheet1_Cationic lipid-assisted nanoparticles for simultaneous delivery of CD47 siRNA and R848 to promote antitumor immune responses.docx حسب Simin Li (314006)

"…Mechanistically, downregulation of CD47 expression and activation of DCs took part in promoting the immune response of cytotoxic T cells (CTLs). Meanwhile, a decrease of myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) indicated the modulating of the tumor immune microenvironment.…"

Table_1_Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer.DOCX حسب Terese Geraghty (8873387)

"…The profiling also showed a significant decrease in CCL2 levels and a concomitant reduction in Ly6C^hi monocytes in circulation in both groups. …"

Table_2_Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer.DOCX حسب Terese Geraghty (8873387)

"…The profiling also showed a significant decrease in CCL2 levels and a concomitant reduction in Ly6C^hi monocytes in circulation in both groups. …"

Image_3_Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer.TIFF حسب Terese Geraghty (8873387)

"…The profiling also showed a significant decrease in CCL2 levels and a concomitant reduction in Ly6C^hi monocytes in circulation in both groups. …"

Image_1_Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer.TIFF حسب Terese Geraghty (8873387)

"…The profiling also showed a significant decrease in CCL2 levels and a concomitant reduction in Ly6C^hi monocytes in circulation in both groups. …"

Data Sheet 1_TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury.zip حسب Yunsheng Zhang (474242)

"…While triggering receptor expressed on myeloid cells-1 (TREM-1) is a key inflammatory amplifier, its mechanistic role and therapeutic potential in TBI remain elusive. …"

Image_2_Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer.TIFF حسب Terese Geraghty (8873387)

"…The profiling also showed a significant decrease in CCL2 levels and a concomitant reduction in Ly6C^hi monocytes in circulation in both groups. …"

KLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy حسب Dipranjan Laha (6491537)

"…<p>Macroautophagy/autophagy is involved in myeloid cellular repair, destruction, and osteoclast differentiation; conversely, KLF2 (kruppel-like factor 2 [lung]) regulates myeloid cell activation and differentiation. …"

DataSheet1_Anti-cancer activity of guggulsterone by modulating apoptotic markers: a systematic review and meta-analysis.docx حسب Meenakshi Gupta (3462941)

"…A total of 40 articles were included in the systematic review and of them, 23 articles were included in the meta‐analysis.The cancerous cell lines used in the studies were for pancreatic cancer, hepatocellular carcinoma, head and neck squamous cell carcinoma, cholangiocarcinoma, oesophageal adenocarcinoma, prostrate cancer, colon cancer, breast cancer, gut derived adenocarcinoma, gastric cancer, colorectal cancer, bladder cancer, glioblastoma, histiocytic leukemia, acute myeloid leukemia and non-small cell lung cancer. The reliability of the selected studies was assessed using ToxRTool.…"

DataSheet2_Anti-cancer activity of guggulsterone by modulating apoptotic markers: a systematic review and meta-analysis.docx حسب Meenakshi Gupta (3462941)

"…A total of 40 articles were included in the systematic review and of them, 23 articles were included in the meta‐analysis.The cancerous cell lines used in the studies were for pancreatic cancer, hepatocellular carcinoma, head and neck squamous cell carcinoma, cholangiocarcinoma, oesophageal adenocarcinoma, prostrate cancer, colon cancer, breast cancer, gut derived adenocarcinoma, gastric cancer, colorectal cancer, bladder cancer, glioblastoma, histiocytic leukemia, acute myeloid leukemia and non-small cell lung cancer. The reliability of the selected studies was assessed using ToxRTool.…"

DataSheet1_Mesenchymal Stromal Cell-Derived Extracellular Vesicles Modulate Hematopoietic Stem and Progenitor Cell Viability and the Expression of Cell Cycle Regulators in an Age-d... حسب Pascal Fichtel (12705212)

"…<p>Aging of the hematopoietic system is characterized by an expansion of hematopoietic stem and progenitor cells (HSPCs) with reduced capacity for engraftment, self-renewal, and lymphoid differentiation, resulting in myeloid-biased hematopoiesis. This process is mediated by both HSPC intrinsic and extrinsic factors, e.g., the stromal environment. …"

DataSheet_1_Nlrp12 deficiency alters gut microbiota and ameliorates Faslpr-mediated systemic autoimmunity in male mice.pdf حسب Leila Abdelhamid (6985811)

"…We hypothesized that NLRP12 would modulate myeloid cells and T cell function to control systemic autoimmunity. …"