A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells <i>In Vitro</i> and Shows Antitumor Effects <i>In Vivo</i> حسب Laia Josa-Culleré (2736559)

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Survivorship of zebrafish embryos decreased and malformations increased across all treatment time periods as PCP concentrations increased. حسب Aleeza Namit (12295157)

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miR-1469 expression inhibits melanoma cell invasiveness. حسب Mallory J. DiVincenzo (11372420)

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miR-1469 expression reduces migration of melanoma cells. حسب Mallory J. DiVincenzo (11372420)

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Hematopoietic-specific loss of Zeb1 leads to differentiation defects in myeloid lineages and specific HSPC populations. حسب Jueqiong Wang (11467505)

"…<b>(C)</b> Flow cytometric analysis of PB of reconstituted mice showed defects in <i>Zeb1</i> null HSPC contribution to myeloid cells (Cd11b⁺) including monocytic (Cd11b⁺Ly6G⁻) and NEU (Cd11b⁺Ly6G⁺) lineage cells. …"

Expression analysis of downstream target genes in the p38/MAPK signaling pathway across myeloid leukemia cell lines. حسب Ajeet P. Singh (22298432)

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Table 1_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.docx حسب Feifei Yang (334047)

"…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …"

Image 4_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.png حسب Feifei Yang (334047)

"…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …"

Image 2_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.png حسب Feifei Yang (334047)

"…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …"

Table 2_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.doc حسب Feifei Yang (334047)

"…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …"

Image 3_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.png حسب Feifei Yang (334047)

"…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …"

Table 3_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.xlsx حسب Feifei Yang (334047)

"…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …"

Image 1_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.png حسب Feifei Yang (334047)

"…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …"

Image 5_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.png حسب Feifei Yang (334047)

"…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …"

miR-1469 expression in melanoma tissue and melanoma cell lines. حسب Mallory J. DiVincenzo (11372420)

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Hepatocyte-specific IL10-deficiency correlates with decreased B cell and patrolling monocyte numbers, increased MHC-II expression on inflammatory monocytes and increased PMN number... حسب Benoit Stijlemans (4567573)

Rosa26 locus–based Zeb2 hematopoietic-restricted overexpression leads to extramedullary hematopoiesis/splenomegaly, enhanced myeloid cell development, and monocyte lineage skewing.... حسب Jueqiong Wang (11467505)

Table_1_Mass cytometry reveals the corneal immune cell changes at single cell level in diabetic mice.docx حسب Limin Qin (10875474)

"…Comprehensive immunological profiling indicated remarkable changes in the immune microenvironment in diabetic corneas, characterized by a notable decrease in CD103+CD8+ tissue-resident memory T (T_RM) cells and Tregs, as well as a dramatic increase of γδT cells and subsets of CD11b+Ly6G+ myeloid-derived suppressor cells (MDSCs).…"

Table_2_Mass cytometry reveals the corneal immune cell changes at single cell level in diabetic mice.docx حسب Limin Qin (10875474)

"…Comprehensive immunological profiling indicated remarkable changes in the immune microenvironment in diabetic corneas, characterized by a notable decrease in CD103+CD8+ tissue-resident memory T (T_RM) cells and Tregs, as well as a dramatic increase of γδT cells and subsets of CD11b+Ly6G+ myeloid-derived suppressor cells (MDSCs).…"

Adaptive phenotypic modulations lead to therapy resistance in chronic myeloid leukemia cells حسب Seda Baykal-Köse (8501583)

"…CD34 negativity, high expression of E-cadherin and CD44; decreased levels of CD45 and β-catenin do not fully confer with the leukemic stem cell (LSC) phenotype. …"