DataSheet_1_Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells.pdf by Wei Huang (36889)

“…<p>Myeloid-derived suppressor cells (MDSCs) are a hetero geneous group of cells, which can suppress the immune response, promote tumor progression and impair the efficacy of immunotherapies. …”

Data_Sheet_1_Activation of the IL-4/STAT6 Signaling Pathway Promotes Lung Cancer Progression by Increasing M2 Myeloid Cells.pdf by Cuiping Fu (3418520)

“…STAT6 deficiency also decreased the mobilization and differentiation of CD11b⁺ cells. …”

Presentation_1_Preventive CCL2/CCR2 Axis Blockade Suppresses Osteoclast Activity in a Mouse Model of Rheumatoid Arthritis by Reducing Homing of CCR2hi Osteoclast Progenitors to the... by Darja Flegar (4113583)

Table_1_Targeting immunosuppressive Ly6C+ classical monocytes reverses anti-PD-1/CTLA-4 immunotherapy resistance.xlsx by B. Leticia Rodriguez (1953484)

“…Mechanistically we found that classical monocytes from ICB resistant tumors were unable to differentiate into antigen presenting cells and instead differentiated into immunosuppressive M2 macrophages or myeloid-derived suppressor cells (MDSC). Classical Ly6C+ monocytes from ICB resistant tumors had a decrease in both Flt3 and PU.1 expression that prevented differentiation into dendritic cells/macrophages.…”

Presentation_1_Targeting immunosuppressive Ly6C+ classical monocytes reverses anti-PD-1/CTLA-4 immunotherapy resistance.pptx by B. Leticia Rodriguez (1953484)

“…Mechanistically we found that classical monocytes from ICB resistant tumors were unable to differentiate into antigen presenting cells and instead differentiated into immunosuppressive M2 macrophages or myeloid-derived suppressor cells (MDSC). Classical Ly6C+ monocytes from ICB resistant tumors had a decrease in both Flt3 and PU.1 expression that prevented differentiation into dendritic cells/macrophages.…”

DataSheet_1_Combining all-trans retinoid acid treatment targeting myeloid-derived suppressive cells with cryo-thermal therapy enhances antitumor immunity in breast cancer.docx by Yue Lou (2831324)

“…<p>Targeting myeloid-derived suppressive cells (MDSCs) has been considered a potential strategy in tumor therapy. …”

Silencing NPM1 impairs rRNA precursor levels in wt/S34F cells. by Abdalla Akef (224557)

Nemp1 supports NE openings in erythroblasts. by Didier Hodzic (132944)

“…<p>(<b>A</b>) Immunodetection of endogenous NEMP1 in lysates from WT and Nemp1 KO myeloid (CD11b+) and erythroid (Ter119+) cells. Histone3 was used as a loading control and Ter119 to confirm myeloid/erythroid sorting specificity. …”

Optimisation of read depth, DNA quantity, and unique alternate observation threshold. by Melinda L. Tursky (20790436)

MtDNA replacement in human oocytes with MRR-SCCT procedure. by Xiaoyu Liao (8161995)

MtDNA residual levels and chromosomal copy numbers in mouse SCC transferred blastocysts. by Xiaoyu Liao (8161995)

MtDNA carryover removal and SCC integraty by MRR manipulation in mouse oocytes. by Xiaoyu Liao (8161995)

Lamina propria dendritic cells, neutrophils, and macrophages produce IL-12p40 in the absence of MyD88 during <i>T</i>. <i>gondii</i> infection. by Lindsay M. Snyder (4975163)

DataSheet_1_TREM2 is associated with tumor immunity and implies poor prognosis in glioma.docx by Mingchen Yu (11807669)

“…<p>Triggering receptor expressed on myeloid cells 2 (TREM2) is expressed in myeloid cells of the central nervous system (CNS), which mediate the immunological response in a variety of diseases. …”

DataSheet_1_Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors.docx by Siddhi N. Paudel (18877030)

“…Additionally, targeting myeloid cells with the myelomodulatory therapy trabectedin, a small molecule activator of caspase-8 dependent apoptosis, augmented the survival benefit of T-VEC in a less immunogenic MPNST model. …”

DataSheet_1_Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors.docx by Siddhi N. Paudel (18877030)

“…Additionally, targeting myeloid cells with the myelomodulatory therapy trabectedin, a small molecule activator of caspase-8 dependent apoptosis, augmented the survival benefit of T-VEC in a less immunogenic MPNST model. …”

Supplementary Tables S1 and S2 by Thomas Clanton (9323303)

“…Here we tested the LPS-responsiveness of mouse soleus when a critical toll receptor adapter protein, (Myd88) was knocked out of all myeloid-derived cells (largely resident macrophages). …”

DataSheet1_Cationic lipid-assisted nanoparticles for simultaneous delivery of CD47 siRNA and R848 to promote antitumor immune responses.docx by Simin Li (314006)

“…Mechanistically, downregulation of CD47 expression and activation of DCs took part in promoting the immune response of cytotoxic T cells (CTLs). Meanwhile, a decrease of myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) indicated the modulating of the tumor immune microenvironment.…”

Table_1_Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer.DOCX by Terese Geraghty (8873387)

“…The profiling also showed a significant decrease in CCL2 levels and a concomitant reduction in Ly6C^hi monocytes in circulation in both groups. …”

Table_2_Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer.DOCX by Terese Geraghty (8873387)

“…The profiling also showed a significant decrease in CCL2 levels and a concomitant reduction in Ly6C^hi monocytes in circulation in both groups. …”