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greater disease » greater distance (Expand Search), greater decrease (Expand Search), related disease (Expand Search)
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greater disease » greater distance (Expand Search), greater decrease (Expand Search), related disease (Expand Search)
large decrease » marked decrease (Expand Search), large increases (Expand Search), large degree (Expand Search)
far greater » fold greater (Expand Search)
b marked » _ marked (Expand Search), a marked (Expand Search), _ market (Expand Search)
n marked » _ marked (Expand Search), a marked (Expand Search), _ market (Expand Search)
a large » _ large (Expand Search)
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Lamin-B protein marks the onset of physiological decline in young adult male <i>Drosophila</i>.
Published 2022Subjects: -
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Deletion of Ssp2 or/and Gsk3/Gsk31 markedly suppressed CLZ, TER or CoCl<sub>2</sub>-induced Sre1 activity.
Published 2020“…<p>The Δ<i>ssp2</i>, Δ<i>gsk3</i>Δ<i>gsk31</i>, Δ<i>ssp2</i>Δ<i>gsk3</i>, Δ<i>ssp2</i>Δ<i>gsk31</i> or Δ<i>ssp2</i>Δ<i>gsk3</i>Δ<i>gsk31</i> cells showed a significant decrease in Sre1 activity and delay in the peak rising of the SRE2 reporter stimulated with 8 μg/ml CLZ (A)<sub>,</sub> 8 μg/ml TER (B) or 0.32 mM CoCl<sub>2</sub> (C). …”
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<b>Effects of marked weight loss induced by gastric bypass surgery or low-calorie diet alone on postprandial glucose disposal in type 2 diabetes</b>
Published 2025“…<p dir="ltr">We used a dual (intravenous and oral) glucose tracer protocol to evaluate rates of glucose appearance into the circulation, insulin-mediated glucose disposal (IMGD), and non-insulin-mediated glucose disposal (NIMGD) for four hours after consumption of a mixed meal in people with obesity and type 2 diabetes before and after marked (~20%) weight loss, induced by behavioral diet therapy (BDT, n=11) or Roux-en-Y gastric bypass (RYGB) surgery (n=9).…”
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<b>The loss of insulin-positive cell clusters precedes the decrease of islet frequency and beta cell area in type 1 diabetes</b>
Published 2025“…Insulin-positive (INS+) single cells (≤10µm), cell clusters (>10 to <35µm), small- and medium-sized islets (35-100µm and 100-200µm) were significantly lost at type 1 diabetes onset, while large INS+ islets (>200µm) were preserved. Moreover, changes in endocrine composition also occurred in mAAb+ donors, including a significant decrease in the INS+ islet fraction. …”