Deviations of the <i>Bound</i> model protein dimer conformation from the reference crystal structure of the channel (PDBID: 2M6X). Por Oluwatoyin Campbell (14392137)

Imlunestrant: First Approval Por Susan J. Keam (6594447)

“...This article summarizes the milestones in the development of imlunestrant leading to this first approval for use in patients with ER+, HER2-, ESR1-mutated advanced or metastatic breast cancer....”

Direct Numerical Simulation Dataset of Turbulent Channel Flow at Re_tau=180 Por Pablo Portero (22639367)

The time-course of information alignment, split by first and second experiment half. Por Denise Moerel (9080849)

“...<p><b>(A)</b> The time-course of the information alignment between the two participants in each pair for the first experiment half (light blue), and the second experiment half (purple). ...”

Comparing Force Field Treatments in QM/MM Studies of the SARS-CoV‑2 RNA-Dependent RNA Polymerase (RdRp) Mechanism Por Maite Roca (1678066)

“...This mechanism was found to be exergonic, with the rate-determining step being the nucleophilic attack, having a free energy barrier of 15.2 kcal mol^–1. ...”

A Graph Neural Network for Small-Area Estimation: Integrating Spatial Regularisation, Heterogeneous Spatial Units, and Bayesian Inference Por Pengyuan Liu (21997418)

“...(Optional) Execute the first installation cell to install any missing packages....”

Distribution of (A) historical and contemporary estimated species richness of 51 medium- to large-bodied mammal species across the entire Caatinga dry forest of northeastern Brazil... Por Nathália Fernandes Canassa (22676541)

Development of FBXO22 Degraders and the Recruitment Ligand 2‑Pyridinecarboxyaldehyde (2-PCA) Por Tian Qiu (156003)

“...Finally, we found that 2-pyridinecarboxaldehyde (2-PCA) functions as a novel electrophilic degron capable of forming a reversible thioacetal with cysteine 326 for recruiting FBXO22. ...”

Development of FBXO22 Degraders and the Recruitment Ligand 2‑Pyridinecarboxyaldehyde (2-PCA) Por Tian Qiu (156003)

“...Finally, we found that 2-pyridinecarboxaldehyde (2-PCA) functions as a novel electrophilic degron capable of forming a reversible thioacetal with cysteine 326 for recruiting FBXO22. ...”

Application of STUPPIT to identify novel intermediary proteins between SMAD4 and β-catenin, central hubs of BMP and Wnt pathway. Por Lin Xie (136792)

“...Underlying mass spectrometry data can be found in the ProteomeXchange (PXD069286).</p>...”

Analysis of the binding site of NagS and activity of NagS mutants. Por Chao Li (145513)

“...<p><b>(a)</b> NagS active site with bound GlcNAc-6P (gray carbons), protein residues are coloured with pale blue and yellow carbons to indicate the 2 monomers forming the active site. 2|Fo|-|Fc| electron density contoured at 1.2 σ is shown as cyan mesh. ...”

Initial simulation coordinates. Por Oluwatoyin Campbell (14392137)

Tilt angle conformational landscapes of residues involved in 1-to-1 helix contacts during the last 500 ns of trajectory in the <i>Surface</i> model. Por Oluwatoyin Campbell (14392137)

Tilt angle conformational landscapes of residues involved in 1-to-1 helix contacts during the last 200 ns of trajectory in the <i>Sep</i> model. Por Oluwatoyin Campbell (14392137)

Root mean square deviation measurements of monomers. Por Oluwatoyin Campbell (14392137)

“...<p><b>A)</b> RMSD of monomer 1 (p1) and <b>B)</b> monomer 2 (p2) calculated using the first frame of each protein as the reference in each case. ...”

Residue contact comparison with reference dimer structure. Por Oluwatoyin Campbell (14392137)

Protein conformational dynamics induced by presence of a lipid membrane. Por Oluwatoyin Campbell (14392137)

Suggested set of research activities and tools for the RITEC (Children's Digital Play and Well-being) research project Por Fiona Scott (6434120)

“...</p><p dir="ltr"><br></p><p dir="ltr"><b>Visit 3 ‘Two weeks post-DPE’</b><br>Around two weeks after Visit 2, researchers conducted further interviews and video observations to understand ongoing use of the game. ...”

النقض المكسور عند الأُصوليين Por Quteish, Hamzah

Obter o texto integral

Image 1_Dynamic duos: learning to care as a pair in the biparental prairie vole (Microtus ochrogaster).jpeg Por Taylor D. Hinton (22687397)

“...</p>Methods<p>We investigated how prairie voles learn to be parents by observing how their parental care effort changes over two consecutive litters. The first litter represents a naive context while the second litter represents an experienced context....”