Deviations of the <i>Bound</i> model protein dimer conformation from the reference crystal structure of the channel (PDBID: 2M6X). ‌ Oluwatoyin Campbell (14392137)

Data Sheet 1_Snoring sound classification in patients with cerebrovascular stenosis based on an improved ConvNeXt model.pdf ‌ Caijian Hua (10169614)

“…To address this gap, this paper proposes a snoring classification method integrating dynamic convolution and attention mechanisms, and explores the acoustic feature differences between patients with cerebrovascular stenosis and those without stenosis.</p>Methods<p>First, we collected nocturnal snoring sounds from 31 patients diagnosed with OSAHS, including 16 patients with cerebrovascular stenosis, and extracted four types of acoustic features: Mel spectrogram, Mel-frequency cepstral coefficients (MFCCs), Constant Q Transform (CQT) spectrogram, and Chroma Energy Normalized Statistics (CENS). …”

Imlunestrant: First Approval ‌ Susan J. Keam (6594447)

“…This article summarizes the milestones in the development of imlunestrant leading to this first approval for use in patients with ER+, HER2-, ESR1-mutated advanced or metastatic breast cancer.…”

Direct Numerical Simulation Dataset of Turbulent Channel Flow at Re_tau=180 ‌ Pablo Portero (22639367)

Comparing Force Field Treatments in QM/MM Studies of the SARS-CoV‑2 RNA-Dependent RNA Polymerase (RdRp) Mechanism ‌ Maite Roca (1678066)

“…This mechanism was found to be exergonic, with the rate-determining step being the nucleophilic attack, having a free energy barrier of 15.2 kcal mol^–1. …”

A Graph Neural Network for Small-Area Estimation: Integrating Spatial Regularisation, Heterogeneous Spatial Units, and Bayesian Inference ‌ Pengyuan Liu (21997418)

“…(Optional) Execute the first installation cell to install any missing packages.…”

Development of FBXO22 Degraders and the Recruitment Ligand 2‑Pyridinecarboxyaldehyde (2-PCA) ‌ Tian Qiu (156003)

“…Finally, we found that 2-pyridinecarboxaldehyde (2-PCA) functions as a novel electrophilic degron capable of forming a reversible thioacetal with cysteine 326 for recruiting FBXO22. …”

Development of FBXO22 Degraders and the Recruitment Ligand 2‑Pyridinecarboxyaldehyde (2-PCA) ‌ Tian Qiu (156003)

“…Finally, we found that 2-pyridinecarboxaldehyde (2-PCA) functions as a novel electrophilic degron capable of forming a reversible thioacetal with cysteine 326 for recruiting FBXO22. …”

Application of STUPPIT to identify novel intermediary proteins between SMAD4 and β-catenin, central hubs of BMP and Wnt pathway. ‌ Lin Xie (136792)

“…Underlying mass spectrometry data can be found in the ProteomeXchange (PXD069286).</p>…”

Initial simulation coordinates. ‌ Oluwatoyin Campbell (14392137)

Tilt angle conformational landscapes of residues involved in 1-to-1 helix contacts during the last 500 ns of trajectory in the <i>Surface</i> model. ‌ Oluwatoyin Campbell (14392137)

Tilt angle conformational landscapes of residues involved in 1-to-1 helix contacts during the last 200 ns of trajectory in the <i>Sep</i> model. ‌ Oluwatoyin Campbell (14392137)

Root mean square deviation measurements of monomers. ‌ Oluwatoyin Campbell (14392137)

“…<p><b>A)</b> RMSD of monomer 1 (p1) and <b>B)</b> monomer 2 (p2) calculated using the first frame of each protein as the reference in each case. …”

Residue contact comparison with reference dimer structure. ‌ Oluwatoyin Campbell (14392137)

Protein conformational dynamics induced by presence of a lipid membrane. ‌ Oluwatoyin Campbell (14392137)

Analysis of the binding site of NagS and activity of NagS mutants. ‌ Chao Li (145513)

“…<p><b>(a)</b> NagS active site with bound GlcNAc-6P (gray carbons), protein residues are coloured with pale blue and yellow carbons to indicate the 2 monomers forming the active site. 2|Fo|-|Fc| electron density contoured at 1.2 σ is shown as cyan mesh. …”

النقض المكسور عند الأُصوليين ‌ Quteish, Hamzah

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Image 1_Dynamic duos: learning to care as a pair in the biparental prairie vole (Microtus ochrogaster).jpeg ‌ Taylor D. Hinton (22687397)

“…</p>Methods<p>We investigated how prairie voles learn to be parents by observing how their parental care effort changes over two consecutive litters. The first litter represents a naive context while the second litter represents an experienced context.…”

عدم التحرز وأثره في إيجاب الضمان في الفقه الإسلامي ‌ Alzyadat, Emad Abdel Hafiz

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Suggested set of research activities and tools for the RITEC (Children's Digital Play and Well-being) research project ‌ Fiona Scott (6434120)

“…</p><p dir="ltr"><br></p><p dir="ltr"><b>Visit 3 ‘Two weeks post-DPE’</b><br>Around two weeks after Visit 2, researchers conducted further interviews and video observations to understand ongoing use of the game. …”