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marked decrease » marked increase (Expand Search)
latent decrease » latency decreased (Expand Search), largest decrease (Expand Search), content decreased (Expand Search)
large decrease » larger decrease (Expand Search), large increases (Expand Search)
large degree » change degree (Expand Search)
i marked » _ marked (Expand Search), _ market (Expand Search), _ marker (Expand Search)
a latent » _ latent (Expand Search), _ patent (Expand Search)
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<b>The loss of insulin-positive cell clusters precedes the decrease of islet frequency and beta cell area in type 1 diabetes</b>
Published 2025“…Insulin-positive (INS+) single cells (≤10µm), cell clusters (>10 to <35µm), small- and medium-sized islets (35-100µm and 100-200µm) were significantly lost at type 1 diabetes onset, while large INS+ islets (>200µm) were preserved. Moreover, changes in endocrine composition also occurred in mAAb+ donors, including a significant decrease in the INS+ islet fraction. …”
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MEDOC: A Fast, Scalable, and Mathematically Exact Algorithm for the Site-Specific Prediction of the Protonation Degree in Large Disordered Proteins
Published 2025“…To address this problem, we developed "multisite extent of deprotonation originating from context" (MEDOC) to determine the degree of protonation of a protein based on the local sequence context of each ionizable residue. …”