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A homozygous point mutation in the <i>Mrps34</i> gene causes a decrease in the MRPS34 protein.
Published 2015“…Sequences used were obtained from GenBank at NCBI (human, <i>Homo sapiens</i>, NP_076425.1; chimp, <i>Pan troglodytes</i>, XP_001160122.1; monkey, <i>Macaca mulatta</i>, NP_001244544.1; mouse, <i>Mus musculus</i>, NP_081622.1; rat, <i>Rattus norvegicus</i>, NP_001099241.1; cow, <i>Bos taurus</i>, NP_001192540.1; dog, <i>Canis lupus familiaris</i>, XP_003639160.1; chicken, <i>Gallus gallus</i>, NP_001264526.1; frog, <i>Xenopus tropicalis</i>, NP_001004910.2; zebrafish, <i>Danio rerio</i>, NP_001007377.2) and the alignment was produced using ClustalW2 [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005089#pgen.1005089.ref041" target="_blank">41</a>]. …”
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Decrease in number of activated macrophages in demyelinated nerves subjected to 1hr ES.
Published 2014“…Note: ES results in a significant decrease in the ED-1 IF 10d post-LPC (5d post-ES; K) and 12d post-LPC (7d post-ES; N) relative to LPC only in a pattern suggestive of movement toward lateral edges and egress (arrow). …”
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OCA alone markedly decreases and combined with Gemcitabine or Cisplatin abrogates growth of iCCA xenografts.
Published 2019“…After 4 weeks, when the tumor size was approximately 100 mm<sup>3</sup> (T<sub>0</sub>) mice were treated with OCA (0.03% w/w, 30 mg/kg) alone or combined with Cisplatin (2.4 mg/Kg in 100 μl) or Gemcitabine (1.05 mg/Kg in 100 μl) for 5 additional weeks. a) Results are expressed as percent increase in tumor volume at different time points. …”
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MK-STYX decreases RhoA activation.
Published 2014“…<p>(<b>A</b>) PC12 cells were transfected with pMT2 or pMT2-FLAG-MK-STYX-FLAG. 24 hr post-transfection cells were stimulated with 100 ng/ml NGF, and lysed at the indicated time points. …”
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Decreased oscillatory flow decreases <i>klf2a</i> expression.
Published 2009“…(L) Quantitative RT-PCR showing the expression level of several flow-responsive genes after lidocaine treatment. <i>klf2a</i> expression is significantly decreased after 6 and 10 h of treatment and is restored by incubation at 34°C; 100% of expression corresponds to a normal expression level. …”