COMET: A Machine-Learning Framework Integrating Ligand-Based and Target-Based Algorithms for Elucidating Drug Targets by Haojie Wang (3072141)

“…We have developed a computational target-fishing method, termed COMET, which integrates ligand-based similarity scores with target-based binding scores into a random forest algorithm for target ranking. …”

COMET: A Machine-Learning Framework Integrating Ligand-Based and Target-Based Algorithms for Elucidating Drug Targets by Haojie Wang (3072141)

“…We have developed a computational target-fishing method, termed COMET, which integrates ligand-based similarity scores with target-based binding scores into a random forest algorithm for target ranking. …”

COMET: A Machine-Learning Framework Integrating Ligand-Based and Target-Based Algorithms for Elucidating Drug Targets by Haojie Wang (3072141)

“…We have developed a computational target-fishing method, termed COMET, which integrates ligand-based similarity scores with target-based binding scores into a random forest algorithm for target ranking. …”

The relevant data file for this article. by Linsha Liu (20378293)

IAM and IEM muxes control code. by Ayesha Waris (21368446)

“…The presented architectures are implemented on Xilinx Artix-7 XC7A100T-3 device using Vivado Design Suite 2022.2 and coded using Verilog HDL. …”

PATH has state-of-the-art performance versus previous binding affinity prediction algorithms. by Yuxi Long (11024307)

Subjects:

Scatter plots of PATH⁺ and our implementation of TNet-BP’s predictions on a held-out, test subset of PDBBind v2020 refined set for one run (90:10 train:test split ratio,... by Yuxi Long (11024307)

Subjects:

Parameter configuration for ChildEmoNet algorithm implementation. by Zhang Shanshan (22272359)

Relevant computed image data. by Zhaoyu Ku (20660546)

Illustration of the recursive objective space exploration process implemented by the ROSE algorithm. by Ihab Hashem (21156806)

Summary of relevant works. by Bashir Olaniyi Sadiq (22478011)

Flow chart of implementation of metaheuristic algorithm-PI control BLDC motor. by Fizza Shafique (19996292)

Main code. by Jingguo Bi (21439766)

The relevant code in the manuscript can be found in the supporting information data file. by Xini Fang (20861990)

Model-relevant variable data for external patients. by Lei Gao (6566)

Relevant data underlying the findings described in manuscript. by Lin Qi (128224)

Data generation algorithm. by Aluwani Ramalata (21262977)

Relevant Parameters. by Dongyan Wang (195482)

The details of the results related to the evaluated algorithms. by Mohammadreza Namdar (22439057)

Resource utilization of modules in proposed implementations. by Ayesha Waris (21368446)