Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells حسب Ejlal Abu-El-Rub (5168183)

"…Similarly, genetic knockdown of HSP90 in RKO cells produced comparable effects, including reduced cell survival and a decreased PINK1/BNIP3 ratio.</p><h3>Conclusion</h3><p dir="ltr">Targeting HSP90 in colon cancer cells disrupts their survival by decreasing PINK1 and increasing BNIP3, which activates oxidative and endoplasmic reticulum stress, ultimately triggering apoptosis.…"

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells حسب Nihal AlMuraikhi (6002234)

"…BMS-833923, a SMO antagonist/Hedgehog inhibitor, exhibited significant inhibitory effects on osteoblast differentiation of hMSCs reflected by decreased ALP activity, in vitro mineralization, and downregulation of osteoblast-related gene expression. …"

Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index حسب Abu Saleh Md Moin (6189512)

"…It is reported that PCOS subjects show marked platelet dysfunction and decreased plasma fibrinolytic activity, resulting in a prothrombotic state. …"

Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells حسب Mohamed Qasim, Al-Fahdawi

"…Pt/MgO nanoparticles also induced production of reactive oxygen species, decreased cellular glutathione level, and increased lipid peroxidation. …"
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Pharmacist Role in Hypertension Management in the Community Setting: Questionnaire Development, Validation, and Application حسب Lama Soubra (11666333)

"…Patient satisfaction from the provided interventions/services was determined by means of an overall rating. The correlation between practiced roles and patient satisfaction with received interventions/services was determined.…"

Effects of COVID-19 on Autism Spectrum Disorder in Qatar حسب Fouad A. Alshaban (17281108)

"…Parents also reported decreased access to family and social support networks, as well as decreased quality of clinical and community support. …"

A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country حسب Nancy Zaghloul (14147865)

"…Among SGLT2is, empagliflozin prescriptions showed an increase from 537 (10.65%) to 2881 (34.40%) compared to dapagliflozin, which decreased by the end of 2018 from 4505 (89.35%) to 5494 (65.6%).…"

Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019 حسب Razieh, Hassannejad

"…FindingsIn contrast with the decreasing trend of HF burden globally, EMR showed an increasing trend. …"
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Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment حسب Safa Salim (9186786)

"…However, it remains unclear how these mechanisms relate to sporadic PD, a more common form of PD. Both enteric and central nervous systems have been implicated in the pathogenesis of sporadic PD, thus highlighting the crosstalk between the gut and brain. …"

Optimal management, prevalence, and clinical behavior of saddle pulmonary embolism: A systematic review and meta-analysis حسب Fateen Ata (12217764)

"…The overall SPE-related mortality rate was 8 % (95 % CI: 5.26–10.96). …"

The effect of Hydrogen Peroxide treatments on dental enamel porosity and protein structure and its long-term implications on tooth hardness and optical properties حسب Jelena Eric (21015107)

"…Hardness analysis revealed significant decreases in microhardness in the bleached group compared to the control group (<i>p </i> < 0.05). …"

Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 حسب Brittney S Sheena (9715568)

"…HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cohort-effect" target="_blank">cohort effects</a>. …"

Properties and Microstructure Distribution of High-Performance Thermal Insulation Concrete حسب Malek Mohammad (17150977)

"…This material allows for better thermal insulation properties, thus decreasing the energy usage within the life cycle of the concrete structure. …"

Exploring the LDHC Interactome as Novel Candidate Therapeutic Targets to Advance Breast Cancer Precision Medicine حسب Mariam Ahmed Amin Mohamed Elesnawy (21547187)

"…<p dir="ltr">Breast cancer remains a major health burden worldwide, being the second most commonly diagnosed cancer, and accounting for the highest cancer-related mortality rate among women. Despite decades of advances in cancer care, the identification of therapeutic targets with higher tumor specificity and favorable safety profiles remains a challenge. …"

Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression حسب Rayanah Barnawi (8737584)

"…<p dir="ltr">Recent years have witnessed major progress in development of novel therapeutic agents such as chemotherapy, targeted therapy and immune checkpoint inhibitors for breast cancer. However, cancer-related death remains high especially in triple-negative breast cancer (TNBC) due limited therapeutic options. …"

دور مكاتب الإصلاح والوساطة والتوفيق الأسري في الأردن في الحد من النزاعات الأسرية من وجهة نظر العاملين بها... حسب Al-Oqaili , Amneh Irshied

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Novel proteins implicated in lipid metabolism disorders حسب Nature Research (16552612)

"…After feeding, its expression is decreased, promoting the uptake of dietary lipids in fat tissue. …"

The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms حسب Farah Karam (22330564)

"…<p dir="ltr">Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. …"

SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs حسب Raed Shalaby (3756112)

"…Our results revealed that these selected chalcone analogs increased dopamine levels in the rat hepatoma (H4IIE) cells and decreased the relative mRNA expression of the MAO-B enzyme.…"

Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation حسب Mai S., El-Shoukrofy

"…As well, the expression levels of 20-HETE, Il-1β and TNF-α were decreased in LPS-challenged RAW264.7 macrophages upon treatment with compound 2a. …"
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