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Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans
Published 2021“…We then used genetic and pharmacological methods to define the features of early motor dysfunction of α-synuclein-expressing C. elegans. …”
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262
Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP)
Published 2023“…<h3>Background</h3><p dir="ltr">In line with global trends, cancer incidence and mortality may have decreased for specific types of cancer in Qatar. However, the cancer-related burden on patients, healthcare systems, and the economy is expected to expand; thus, cancer remains a significant public healthcare issue in Qatar. …”
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263
New media and new practices of exploitation
Published 2015“…Standing (2011:6) defines most important quality of precariat as flexibility and quick response to demand while redefining employment as a process rather than a stable condition. …”
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264
Blockchain, climate damage, and death: Policy interventions to reduce the carbon emissions, mortality, and net-zero implications of non-fungible tokens and Bitcoin
Published 2022“…</p><p dir="ltr">Nonetheless, many popular types of blockchain have resisted the pressure to decrease their environmental impact, including Bitcoin, whose attributed 2021 annual emissions will produce emissions responsible for around 19,000 future deaths. …”
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265
Social Media Use and Body Checking Among Lebanese Adults
Published 2022“…That being said, interventions regulating social media content to limit the spread of unrealistic beauty standards and media literacy campaigns educating people may be helpful to decrease body checking behaviors thus decreasing the risk of body image dissatisfaction and disordered eating.…”
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266
eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways
Published 2018“…Furthermore, we show that hippuristanol perturbs the activation of the STAT3 pathway and expression of STAT3-gene targets such as IL-6. The decreased activation of STAT3, which resulted from a decrease in STAT3 protein expression, was due to the inhibition of STAT3 translation as there were no changes in STAT3 mRNA levels. …”
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267
Optical coherence tomography findings in autoimmune retinopathy
Published 2012“…Macular OCT showed reduced central macular and foveal thicknesses in 6 patients (mean thickness 143 ± 30 μm and 131 ± 29 μm respectively). …”
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268
PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications
Published 2019“…Recent studies revealed that enhanced PD-L1 expression in cancer stem cells is linked to immune evasion. Understanding the mechanisms behind this PD-L1 overexpression in cancer stem cells is critical for developing more effective strategies for preventing immune evasion and increasing the efficacy of anti-PD-1/PD-L1 therapy. …”
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Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 2021
Published 2024“…Incidence data were extracted from insurance claims and inpatient discharge sources and analysed with disease modelling meta-regression, version 2.1 (DisMod-MR 2.1). Years of life lost (YLLs) were estimated by combining death counts with standard life expectancy at the age of death. …”
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273
Modeling the influence of daily temperature and precipitation extreme indices on vegetation dynamics in Katsina State using statistical downscaling model (SDM)
Published 2023“…All the scenarios present increasing minimum and maximum temperatures and decreasing precipitation, except for RCP8.5, which predicted a more adverse trend. …”
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274
Using Data Mining and Text Mining Techniques in Predicting the Price of Real Estate Properties in Dubai
Published 2014“…It is found that the results of linear regression prediction have been improved significantly after adding text mining to the experiments. The root mean squared errors RMSEs for all data subsets have decreased leading to enhancing the accuracy of prediction. …”
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275
A modified lipid composition in Fabry disease leads to an intracellular block of the detergent-resistant membrane-associated dipeptidyl peptidase IV
Published 2010“…Fabry disease is an X-linked lysosomal storage disorder that leads to abnormal accumulation of glycosphingolipids due to a deficiency of alpha-galactosidase A (AGAL). …”
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276
Breast cancer cells and bone marrow mesenchymal stromal cells
Published 2017Get full text
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Detecting attacks in a cluster based QOS-OLSR protocol. (c2014)
Published 2014Get full text
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A Power Ripple Compensator for DC Nanogrids via a Solid-State Converter
Published 2020“…This SSC is often considered as the main DC nanogrid energy control unit that is linking the nanogrid with the main utility AC grid and managing the nanogrid elements. …”