Genomic Landscape And Structural Impact Of Biotinidase (BTD) Variants In A Middle Eastern Population حسب BalaSubramani Gattu Linga (19325617)

"…MD simulations indicated that H323R, D444H, and P497S exhibited greater structural flexibility (increased RMSD/RMSF and PCA trace values), whereas R209C and D444H demonstrated reduced compactness (higher radius of gyration). …"

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation حسب Larissa Haertle (3864310)

"…Furthermore, T21 patients have a high risk of developing Alzheimer’s disease (AD) early in life, characterized by the presence of senile plaques of amyloid protein and neurofibrillary tangles, leading to neuronal loss and cognitive decline. …"

From past famines to present crises: The epigenetic impact of maternal malnutrition on offspring health in Gaza حسب Mohamed Adil Shah Khoodoruth (14589828)

"…It was shown that first-trimester exposure to severe famine during the Dutch Hunger Winter was associated with increased risk of schizophrenia in offsprings (Hoek et al., 1998). …"

Comparative effectiveness of one versus two doses of COVID-19 vaccines in Qatar: Evidence of converging protection over time حسب Hiam Chemaitelly (439114)

"…In contrast to the gradual buildup of protection against infection, single-dose effectiveness against severe, critical, or fatal COVID-19 increased rapidly for all three vaccines, exceeding 85 % by day 21 and closely matching the protection achieved after two doses.…"

Maternal–Neonatal Methylome Signatures In Preterm Birth Revealed By Long-Read DNA Methylation Profiling حسب BalaSubramani Gattu Linga (19325617)

"…Epigenetic regulation, particularly DNA methylation, is increasingly recognized as a key mediator of these processes, yet dual maternal-neonatal methylation landscapes in PTB remain insufficiently characterized. …"

Causes of construction reworks and their mitigation strategies حسب HAYAT, KAMRAN

"…By reducing the reworks , client feel more comfortable and satisfied, company market value increases ,less wastage of material, reduce waste and time, fatigue and tension will be less among staff , more comfortable and safe work environment can be achieved. …"
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Global, regional, and national burden of household air pollution, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 حسب Fiona B, Bennitt

"…We first estimated the mean fuel type-specific concentrations (in μg/m3) of fine particulate matter (PM2·5) pollution to which individuals using solid fuels for cooking were exposed, categorised by fuel type, location, year, age, and sex. …"
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Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study حسب Rupert Bourne (603842)

"…</p><p><br></p><h3>Methods</h3><p dir="ltr">We did a systematic review and meta-analysis of population-based surveys of eye disease from January, 1980, to October, 2018. …"

Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1 حسب Natalie C Galles (9715361)

"…Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020, Release 1, we did a systematic analysis of global, regional, and national vaccine coverage trends using a statistical framework, by vaccine and over time.…"

Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease St... حسب Jessica A, Kerr

"…From 2022 to 2050, global increases in overweight (not obesity) prevalence are forecasted to stabilise, yet the increase in the absolute proportion of the global population with obesity is forecasted to be greater than between 1990 and 2021, with substantial increases forecast between 2022 and 2030, which continue between 2031 and 2050. …"
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New media and new practices of exploitation حسب Uzunoglu, Sarphan

"…Today, in new media sphere, tracking technologies replaced rating systems and data about consumer is being sold. Increasing use of new media and increasing Internet penetration through rising sales numbers of mobile devices caused a necessity for a new debate. …"
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Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 حسب Gregory A. Roth (6302315)

"…The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. …"

Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050 حسب Yingzhao, Jin

"…Between 1990 and 2019, the slope index of inequality increased for six MSK disorders, and the relative concentration index increased for gout, NP, OA, and OMSKDs but decreased for LBP and RA. …"
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The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global B... حسب Saeid Safiri (3713035)

"…</p><p><br></p><h3>Methods</h3><p dir="ltr">Vital registration, sample vital registration, verbal autopsy, and cancer registry data were used to generate incidence, death, and disability-adjusted life-year (DALY) estimates of colorectal cancer at the global, regional, and national levels. …"

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults حسب Nowell H, Phelps

"…InterpretationThe combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. …"
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Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 حسب Valery L Feigin (5320574)

"…From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). …"

Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Bur... حسب Rafael, Lozano

"…We constructed the UHC effective coverage index by weighting each effective coverage indicator relative to its associated potential health gains, as measured by disability-adjusted life-years for each location-year and population-age group. …"
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Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000–17 حسب Aniruddha Deshpande (4377094)

"…More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88·6% (95% UI 87·2–89·7) access overall. …"

Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 حسب Brittney S Sheena (9715568)

"…The number of HBV-related deaths increased between 1990 and 2019 (by 5·9% [–5·6 to 19·2]) and between 2015 and 2019 (by 2·9% [–5·9 to 11·3]). …"

Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000–17 حسب Kirsten E Wiens (9153854)

"…Increases in ORS use corresponded with declines in RHF in many locations, resulting in relatively constant overall ORT coverage from 2000 to 2017. …"