Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans حسب Kevin S. Chen (9201767)

"…We then used genetic and pharmacological methods to define the features of early motor dysfunction of α-synuclein-expressing C. elegans. …"

Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP) حسب Anas Hamad (9545771)

"…<h3>Background</h3><p dir="ltr">In line with global trends, cancer incidence and mortality may have decreased for specific types of cancer in Qatar. However, the cancer-related burden on patients, healthcare systems, and the economy is expected to expand; thus, cancer remains a significant public healthcare issue in Qatar. …"

The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal حسب Abdallah, Jad

"…Both proteins are involved in protection against environmental stresses. Here, we show that, like DJ-1 and Hsp31, they repair glyoxal- and methylglyoxal-glycated proteins. …"
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Western diet induces mild metabolic impairment and aggravates neuropathology in an experimental mouse model of traumatic brain injury حسب Judith, Nwaiwu

"…WD has been shown to impair cognitive function, decrease the brain's capacity to compensate for insult by affecting recovery as well as induce metabolic syndrome (MetS) which may be a risk factor for poor TBI prognosis. …"
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Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019 حسب Razieh, Hassannejad

"…Age-standardised prevalence, YLDs, and underlying causes of HF were compared by 5-year age groups (considering 15 years old and more), sex (male and female), and countries. FindingsIn contrast with the decreasing trend of HF burden globally, EMR showed an increasing trend. …"
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New media and new practices of exploitation حسب Uzunoglu, Sarphan

"…Standing (2011:6) defines most important quality of precariat as flexibility and quick response to demand while redefining employment as a process rather than a stable condition. …"
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State‐dependent control of breathing by the retrotrapezoid nucleus حسب Burke, Peter G. R.

"…Electroencephalogram, neck electromyogram, blood pressure, respiratory frequency (fR) and tidal volume (VT) were recorded in 28 conscious adult male Sprague–Dawley rats. Optogenetic stimulation of RTN with channelrhodopsin-2, or inhibition with archaerhodopsin, simulated an instantaneous increase or decrease of central chemoreceptor activity. …"
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Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats حسب Ines Fki (14571855)

"…Equally, it showed a rise of the apoptotic markers (a decrease in the expression of the Bcl-2 and an increase of the P53). …"

Health in times of uncertainty in the eastern Mediterranean region, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 حسب Mokdad, Ali H

"…However, diarrhoeal diseases were the leading cause of death in Somalia (186·7 deaths per 100 000 people) in 2013, which decreased by 26·9% since 1990. The leading cause of disability-adjusted life-years (DALYs) was ischaemic heart disease for males and lower respiratory infection for females. …"
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Optical coherence tomography findings in autoimmune retinopathy حسب Abazzari, Azin

"…Macular OCT showed reduced central macular and foveal thicknesses in 6 patients (mean thickness 143 ± 30 μm and 131 ± 29 μm respectively). …"
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Reducing terrorism with development ; the United Nations' new path. (c2009) حسب Kassis, Maria-Rita

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PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications حسب Pramod Darvin (153341)

"…In summary, EMT-associated overexpression of PD-L1 was partially independent of promoter CpG methylation and more likely to be dependent on posttranslational histone modifications. …"

eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways حسب Zvi Cramer (10742876)

"…These effects are likely dependent on the inhibition of eIF4A activity since we observed similar results using PatA. …"

The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study حسب Aksam Yassin (14779204)

"…In this single-centre, cumulative, prospective, registry study, 321 hypogonadal men (mean age: 58.9 years) received testosterone undecanoate injections in 12-week intervals for up to 12 years. …"

Modeling the influence of daily temperature and precipitation extreme indices on vegetation dynamics in Katsina State using statistical downscaling model (SDM) حسب Mohammad Hadi Ahmad (17632248)

"…All the scenarios present increasing minimum and maximum temperatures and decreasing precipitation, except for RCP8.5, which predicted a more adverse trend. …"

Using Data Mining and Text Mining Techniques in Predicting the Price of Real Estate Properties in Dubai حسب Khashan, Deena Younis Abo

"…It is found that the results of linear regression prediction have been improved significantly after adding text mining to the experiments. The root mean squared errors RMSEs for all data subsets have decreased leading to enhancing the accuracy of prediction. …"
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Fluid-Structure-Acoustic coupling analysis for external laminar and turbulent fluid flows حسب Tohid, Adibi

"…The results indicate that the transmission loss is 27% more at the elastic plate’s highest position. By decreasing the length of the elastic plate by 50%, the mean transmission loss is reduced by 9%. …"
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Protein Glycation in Plants—An Under-Researched Field with Much Still to Discover حسب Naila Rabbani (291722)

"…We consider dicarbonyl stress, the functional vulnerability of the plant proteome to arginine-directed glycation and the likely role of methylglyoxal-mediated glycation in the activation of the unfolded protein response in plants. …"

Effect of speed and gradient on plantar force when running on an AlterG® treadmill حسب Athol Thomson (6651008)

"…<h3>Background</h3><p dir="ltr">Anti-gravity treadmills are used to decrease musculoskeletal loading during treadmill running often in return to play rehabilitation programs. …"

Organizational climate and its effects on the employees commitment حسب El-Kassar, Abdul-Nasser

"…Herscovitch and Meyer (2002) defined commitment as the extent to which workers recognize the goals and objectives of the organization and they are willing to make effort and to work harder to help it prosper. …"
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