Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments by Gunjan Dagar (9339276)

“…CAR-T therapy has achieved FDA approval for treating blood cancers like B-cell acute lymphoblastic leukemia, large B-cell lymphoma, and multiple myeloma by targeting CD-19 and B-cell maturation antigens. …”

Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression by Rayanah Barnawi (8737584)

“…Herein, fascin ShRNA was used to generate stable fascin knockdown (FSCN1^KD) in the MDA-MB-231 TNBC cell line and then were subjected to comprehensive mRNA and miRNA transcriptome analysis. …”

From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease by Ahmad Raza (18205961)

“…Current vascular insults include the breakdown of the blood-brain barrier (BBB) and decreased brain perfusion, along with other contributory factors to conditions conducive to neurotoxicity. …”

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…Similarly, we observed decreased in vivo ectopic bone formation. Global gene expression profiling of BMS-833923-treated compared to vehicle-treated control cells, identified 348 upregulated and 540 downregulated genes with significant effects on multiple signaling pathways, including GPCR, endochondral ossification, RANK-RANKL, insulin, TNF alpha, IL6, and inflammatory response. …”

Psychological and Coping Strategies Related to Home Isolation and Social Distancing in Children and Adolescents During the COVID-19 Pandemic: Cross-sectional Study by Abduljaleel Abdullatif Zainel (18055382)

“…Higher levels of anger, depression, and general anxiety were prevalent among 1.3% (n=84), 3.9% (n=260), and 1.6% (n=104) of participants, respectively. The mean score for the emotional constructs anger and depression decreased with increased compliance with regulations (<i>P</i>=.04 and <i>P</i>=.11, respectively). …”

Writing and publishing language studies in the Arab region [Khitabaat Journal] by Emad Abdul-latif (21841985)

“…Klein starts from an implicit assumption that writing and reading are individual activities and suggests that (individual) writers must decrease their production to enable their (individual) readers to read it. …”

Evaluation of the Analgesic Effect of Blood Flow Restriction Training in Patients With Anterior Knee Pain by Hani A. Alogaili (19953141)

“…In addition to resistance exercise possible hypoalgesic effect to decrease pain perception, blood flow restriction (BFR) training may furnish a surrogate therapeutic protocol to treat anterior knee pain when added to low intensity quadriceps strengthening. …”

Thermally Conductive Polyethylene/Expanded Graphite Composites as Heat Transfer Surface: Mechanical, Thermo-Physical and Surface Behavior by Patrik Sobolčiak (4401364)

“…Moreover, the surface wettability of the HDPE/EG composite was enhanced by corona and RF plasma treatment as demonstrated by the increase in surface free energy from 28.5 mJ/m2 for untreated HDPE/EG to 55.5 and 54.5 mJ/m2 for HDPE/EG treated by corona and RF plasma, respectively. This enhanced surface wettability was retained over a long time with only a 9% and 18% decrease in RF and corona plasma-treated samples’ surface energy after two months. …”

Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis by Osama Hussein (21301202)

“…In ACG patients, the pooled effect showed a percentage of IOP reduction (IOPR%) of 35.22% with a mean IOP reduction of −9.51 mmHg, <i>p</i>< 0.001 at 12 months, and an IOPR% of 27.47% with a mean reduction of −6.37 mmHg, <i>p</i> < 0.001 at 24 months. …”

Effectiveness of external myofascial mobilisation in the management of male chronic pelvic pain of muscle spastic type: A retrospective study by M. S Ajimsha (21250760)

“…The mean (SD) NIH-CPSI score at initial evaluation was 29.41 (8.3) and decreased to 9.14 (3.45) after the fifth visit. …”

Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications by Fang Yu (156838)

“…They further establish the SOCE hypomorph line as a genetic model to define the therapeutic window of SOCE inhibition and dissect toxicities associated with chronic SOCE inhibition in a tissue-specific fashion.…”

Driving simulation sickness and the sense of presence: Correlation and contributing factors by Mustafa Almallah (17280568)

“…Importantly, designing buildings that replicate a real-world environment could increase SP and decrease SS. Moreover, designing high quality and resolution scenarios could also increase SP, thus decreasing the severity of SS symptoms. …”

Salicylic acid restricts mercury translocation by activating strong antioxidant defense mechanisms in sweet pepper (Capsicum annum L.) by Muhammad Fasih Khalid (10652246)

“…H₂O₂ was found to be lower in plants treated with SA under Hg toxicity than in non-treated plants. …”

Extraction and characterization of biofunctional lignocellulosic fibers from Pulicaria undulata plant and the effect of alkali treatment on their bio-physicochemical properties by Mohammed, Alsafran

“…The raw fiber showed promising radical scavenging and reducing power properties, and demonstrated antifungal activity against Candida albicans. In contrast, alkali-treated fibers showed a significant decrease in radical scavenging activity (almost 7–8 fold) and reducing power potential (6-fold) and exhibited no antifungal activity, potentially due to the loss of bioactive components such as lignin and essential oils. …”
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Crystallization properties of arsenic doped GST alloys by Vinod E. Madhavan (8136774)

“…Optical band gap (E_opt) values of the as-deposited films show a clear increasing trend; 0.6 eV for GST to 0.76 eV for (GST)_0.85As_0.15. The decreases in E_opt for the samples annealed at higher temperatures shows significant optical contrast between the as-deposited and annealed samples. …”

Enhancing the production of biogas through anaerobic co-digestion of agricultural waste and chemical pre-treatments by Fares Almomani (12585685)

“…The improved CMP in the chemically treated substrates reflects a 19% increase in the generated revenue. …”

Simultaneous Bilateral Neck of Femur Fracture in a Young Adult with Underlying Metabolic Disturbances by Eslam Alkaramani (14570439)

“…Ruling out other biological underlying etiologies, early diagnosis and early fracture anatomic reduction and fixation are crucial to decrease potential complications such as avascular necrosis and fracture nonunion. …”

Evaluation of pretreatment and membrane configuration for pressure-retarded osmosis application to produced water from the petroleum industry by Dareen Dardor (17052381)

“…When minimally pretreated PW (10-micron cartridge filtration (CF)) was tested in FLS mode, severe membrane fouling occurred and the PRO flux decreased by 60%. In contrast, HF modules showed <1% flux decrease under both minimal and intermediate pretreatment schemes. …”

Investigating the Impact of Salinity Variations on Aerobic Granules and Activated Sludge Flocs: Emphasis on Performance Monitoring and Identification of Influential Salinity Compon... by Raghavendran Sivasubramanian (16931775)

“…<p dir="ltr">Biological wastewater treatment processes can effectively treat large volumes of wastewater at relative economic advantage. …”

Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP) by Anas Hamad (9545771)

“…<h3>Background</h3><p dir="ltr">In line with global trends, cancer incidence and mortality may have decreased for specific types of cancer in Qatar. …”