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261
Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism
Published 2023“…<p dir="ltr">Children from old fathers carry an increased risk for autism spectrum (ASD) and other neurodevelopmental disorders, which may at least partially be mediated by paternal age effects on the sperm epigenome. …”
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262
Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells <i>via</i> Tryptophan 2,3 Dioxygenase
Published 2022“…Moreover, dex stimulates spherogenesis of both cell lines, which is mediated by TDO, evident by its suppression with 680C91, a TDO inhibitor. …”
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263
The effect of StarD13 on colorectal cancer proliferation and invasion. (c2013)
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masterThesis -
264
ROS-Mediated Autophagic Death in Glioblastoma Cells Upon Treatment by Human Recombinant Arginase I (Co)- PEG5000 [HuArgI (Co)-PEG5000]
Published 2021“…In this study, we examine the mechanism of HuArgI (Co)-PEG5000-induced cell death in both partially and completely auxotrophic GBM cell lines. Our results first showed a significant increase in HuArgI (Co)-PEG5000 treated cells for both U251 and A172 in autophagosome formation; suggesting activation of autophagy in response to arginine deprivation. …”
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masterThesis -
265
The Extent to Which Schools with Mechanistic Structures and their Job Characteristics are Likely to Generate Teachers’ Organisational Commitment: Study Conducted in a Private Schoo...
Published 2020“…Staff are motivated due to their perception of the importance of their roles however an increase in autonomy and authority in decision making as well as diversifying the job skills used during teaching could further increase motivation. …”
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266
Optical coherence tomography findings in autoimmune retinopathy
Published 2012“…Macular OCT showed reduced central macular and foveal thicknesses in 6 patients (mean thickness 143 ± 30 μm and 131 ± 29 μm respectively). …”
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267
Reducing terrorism with development ; the United Nations' new path. (c2009)
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masterThesis -
268
Fluorescein angiography versus superimposed OCT-guided macular laser photocoagulation
Published 2013“…The area of dye leakage on FA and increased retinal thickness on OCT on the same eye was measured using Heidelberg Explorer software. …”
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269
Fluid-Structure-Acoustic coupling analysis for external laminar and turbulent fluid flows
Published 2023“…The results indicate that the transmission loss is 27% more at the elastic plate’s highest position. By decreasing the length of the elastic plate by 50%, the mean transmission loss is reduced by 9%. …”
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270
Dual Targeting of Matrix Metalloproteases and the MAPK Pathway in Acute Myeloid Leukemia Cells Using an MMP-activated anthrax lethal toxin (PrAgL1/LF)
Published 2020“…Our results demonstrate that vertical inhibition does offer increased potency in comparison to single targeting of the MAPK pathway when working with sensitive cell lines that are dependent on the cascade. …”
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masterThesis -
271
Positional and dimensional temporomandibular joint osseous changes in patients treated with the forsus fatigue resistant device: a non-randomized clinical trial
Published 2025“…After alignment and leveling with fixed orthodontic appliances using 0.019 × 0.025-inch stainless-steel archwires, the FFRD was fitted. The overjet was corrected to achieve an edge-to-edge incisor relationship. …”
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272
A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells
Published 2008“…Experimental Design The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …”
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273
A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce...
Published 2008“…Experimental Design: The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …”
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274
Effect of StarD13 on colorectal cancer proliferation, motility and invasion
Published 2014“…Colon cancer is a cancer of the epithelial cells lining the colon. It is mainly divided into different stages according to the invasiveness and metastatic ability of the tumor. …”
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275
Tuberculosis following programmed cell death receptor-1 (PD-1) inhibitor in a patient with non-small cell lung cancer. Case report and literature review
Published 2022“…Nonetheless, tuberculosis (TB) reactivation during their use is increasingly recognized and reported. Herein, we present a 58-year-old lady with advanced non-small cell lung cancer (NSCLC) ALK-negative, EGFR wild, and PD-L1 immune histochemistry (IHC) strongly positive in 95% of tumor cells, on ongoing treatment with Pembrolizumab as a first-line monotherapy. …”
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276
Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer
Published 2021“…To date, immune check-point inhibitors have been approved as first or second line therapy options in a broadening range of metastatic cancer and increasingly explored in the treatment of early stage tumors. …”
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277
PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer
Published 2019“…In this study, we investigated the molecular mechanisms by which the human TNBC cell line MDA-MB-231, expressing PD-L1, responds to atezolizumab, using RNA-Seq. …”
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278
Prevalence and global trends of polypharmacy in patients with chronic kidney disease: A systematic review and meta-analysis
Published 2023“…In line with the therapeutic guidelines, managing CKD and its complications necessitates prescribing multiple medications, which predisposes patients to polypharmacy. …”
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279
Need for Affect, Problematic Social Media Use and the Mediating Role of Fear of Missing Out in European and Arab Samples
Published 2023“…<h3>Purpose </h3><p dir="ltr">The growing awareness and concern about the excessive use of social media have led to an increasing number of studies investigating the underlying factors contributing to this behavior. …”
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280
A Model of Telecommunication Sector Development and Economical Growth in GCC Countries: A Case Study of UAE
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doctoralThesis