Reply to Comments by Kakkar and Dahiya by Chahine, Elias B.

“…TO THE EDITOR: Chahine, Karaoui, and Mansour1 reviewed the efficacy and safety of bedaquiline in the treatment of adults with pulmonary multidrug-resistant tuberculosis (MDR-TB) and generally agree with the comments made by Kakkar and Dahiya.2 Bedaquiline was approved by the Food and Drug Administration based largely on results from phase 2 studies using sputum conversion as a surrogate marker for efficacy rather than long-term mortality data.2 Bedaquiline was shown to be associated with an unfavorable side effect profile, including an unexplained increased risk of mortality, QT prolongation, and elevated liver function tests.2 However, it is important to acknowledge that bedaquiline is the first novel drug to be approved for the treatment of TB in more than 4 decades and the communities devastated by MDR-TB are in desperate need for more options to manage their patients. …”
Get full text
Get full text
Get full text
Get full text

In Vitro and In Vivo Effects of Lebanese Cannabis Oil Against Acute Myeloid Leukemia (AML) by Lteif, Anthony

“…WEHI-3 cells were treated with increasing concentrations of COE to determine the IC50 after 24, 48 and 72-hours post treatment. …”
Get full text
Get full text
Get full text

Towards electric digital twin grid: Technology and framework review by Md. Mhamud Hussen Sifat (17337913)

“…Thus, the power grid transmission loss and location of the overheated line and power connection missing can be detected in addition decision-making and self-healing can possible. …”

Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism by Ramya Potabattula (4401160)

“…<p dir="ltr">Children from old fathers carry an increased risk for autism spectrum (ASD) and other neurodevelopmental disorders, which may at least partially be mediated by paternal age effects on the sperm epigenome. …”

Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells <i>via</i> Tryptophan 2,3 Dioxygenase by Marta Cecchi (21363581)

“…Moreover, dex stimulates spherogenesis of both cell lines, which is mediated by TDO, evident by its suppression with 680C91, a TDO inhibitor. …”

The effect of StarD13 on colorectal cancer proliferation and invasion. (c2013) by Nasrallah, Anita I.

Get full text
Get full text

ROS-Mediated Autophagic Death in Glioblastoma Cells Upon Treatment by Human Recombinant Arginase I (Co)- PEG5000 [HuArgI (Co)-PEG5000] by Abdel Khalek, Maya

“…In this study, we examine the mechanism of HuArgI (Co)-PEG5000-induced cell death in both partially and completely auxotrophic GBM cell lines. Our results first showed a significant increase in HuArgI (Co)-PEG5000 treated cells for both U251 and A172 in autophagosome formation; suggesting activation of autophagy in response to arginine deprivation. …”
Get full text
Get full text
Get full text

The Extent to Which Schools with Mechanistic Structures and their Job Characteristics are Likely to Generate Teachers’ Organisational Commitment: Study Conducted in a Private Schoo... by Mansour, Hadi

“…Staff are motivated due to their perception of the importance of their roles however an increase in autonomy and authority in decision making as well as diversifying the job skills used during teaching could further increase motivation. …”
Get full text

Optical coherence tomography findings in autoimmune retinopathy by Abazzari, Azin

“…Macular OCT showed reduced central macular and foveal thicknesses in 6 patients (mean thickness 143 ± 30 μm and 131 ± 29 μm respectively). …”
Get full text
Get full text
Get full text
Get full text

Development and Mechanical Performance of Sustainable Geopolymer Concrete by Zannerni, Ghina M.

Get full text

Reducing terrorism with development ; the United Nations' new path. (c2009) by Kassis, Maria-Rita

Get full text
Get full text

Fluorescein angiography versus superimposed OCT-guided macular laser photocoagulation by Kozak, Igor

“…The area of dye leakage on FA and increased retinal thickness on OCT on the same eye was measured using Heidelberg Explorer software. …”
Get full text
Get full text
Get full text

Fluid-Structure-Acoustic coupling analysis for external laminar and turbulent fluid flows by Tohid, Adibi

“…The results indicate that the transmission loss is 27% more at the elastic plate’s highest position. By decreasing the length of the elastic plate by 50%, the mean transmission loss is reduced by 9%. …”
Get full text
Get full text
Get full text

Dual Targeting of Matrix Metalloproteases and the MAPK Pathway in Acute Myeloid Leukemia Cells Using an MMP-activated anthrax lethal toxin (PrAgL1/LF) by Al Saneh, Ahmad

“…Our results demonstrate that vertical inhibition does offer increased potency in comparison to single targeting of the MAPK pathway when working with sensitive cell lines that are dependent on the cascade. …”
Get full text
Get full text
Get full text

Positional and dimensional temporomandibular joint osseous changes in patients treated with the forsus fatigue resistant device: a non-randomized clinical trial by Ramy Abdul-Rahman Ishaq (22928974)

“…After alignment and leveling with fixed orthodontic appliances using 0.019 × 0.025-inch stainless-steel archwires, the FFRD was fitted. The overjet was corrected to achieve an edge-to-edge incisor relationship. …”

A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells by Abou-Ghazal, Mohamed K.

“…Experimental Design The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …”
Get full text
Get full text
Get full text
Get full text

A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... by Abou-Ghazal, Mohamed

“…Experimental Design: The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …”
Get full text
Get full text
Get full text
Get full text

Effect of StarD13 on colorectal cancer proliferation, motility and invasion by Nasrallah, Anita

“…Colon cancer is a cancer of the epithelial cells lining the colon. It is mainly divided into different stages according to the invasiveness and metastatic ability of the tumor. …”
Get full text
Get full text
Get full text
Get full text

Tuberculosis following programmed cell death receptor-1 (PD-1) inhibitor in a patient with non-small cell lung cancer. Case report and literature review by Aasir M. Suliman (14150217)

“…Nonetheless, tuberculosis (TB) reactivation during their use is increasingly recognized and reported. Herein, we present a 58-year-old lady with advanced non-small cell lung cancer (NSCLC) ALK-negative, EGFR wild, and PD-L1 immune histochemistry (IHC) strongly positive in 95% of tumor cells, on ongoing treatment with Pembrolizumab as a first-line monotherapy. …”

Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer by Said Dermime (79420)

“…To date, immune check-point inhibitors have been approved as first or second line therapy options in a broadening range of metastatic cancer and increasingly explored in the treatment of early stage tumors. …”